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Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists.
Clark JC, Martin EM, Morán LA, Di Y, Wang X, Zuidscherwoude M, Brown HC, Kavanagh DM, Hummert J, Eble JA, Nieswandt B, Stegner D, Pollitt AY, Herten DP, Tomlinson MG, García A, Watson SP. Clark JC, et al. Among authors: moran la. Commun Biol. 2023 Apr 7;6(1):376. doi: 10.1038/s42003-023-04766-6. Commun Biol. 2023. PMID: 37029319 Free PMC article.
A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade.
Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Morán LA, Lacerenza S, Pinto-Llorente R, Eble JA, de Los Ríos V, Domínguez E, Loza MI, Casal JI, Carrascal M, Abián J, García A. Izquierdo I, et al. Among authors: moran la. Thromb Haemost. 2020 Feb;120(2):262-276. doi: 10.1055/s-0039-3400295. Epub 2020 Jan 4. Thromb Haemost. 2020. PMID: 31901221 Free article.
Phosphoproteomic Analysis of Platelets in Severe Obesity Uncovers Platelet Reactivity and Signaling Pathways Alterations.
Barrachina MN, Hermida-Nogueira L, Moran LA, Casas V, Hicks SM, Sueiro AM, Di Y, Andrews RK, Watson SP, Gardiner EE, Abian J, Carrascal M, Pardo M, García Á. Barrachina MN, et al. Among authors: moran la. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):478-490. doi: 10.1161/ATVBAHA.120.314485. Epub 2020 Nov 5. Arterioscler Thromb Vasc Biol. 2021. PMID: 33147989 Free article.
The PI3Kδ Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential.
Barrachina MN, Izquierdo I, Hermida-Nogueira L, Morán LA, Pérez A, Arroyo AB, García-Barberá N, González-Conejero R, Troitiño S, Eble JA, Rivera J, Martínez C, Loza MI, Domínguez E, García Á. Barrachina MN, et al. Among authors: moran la. Int J Mol Sci. 2021 Mar 24;22(7):3304. doi: 10.3390/ijms22073304. Int J Mol Sci. 2021. PMID: 33804911 Free PMC article.
Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist.
Morán LA, Di Y, Sowa MA, Hermida-Nogueira L, Barrachina MN, Martin E, Clark JC, Mize TH, Eble JA, Moreira D, Pollitt AY, Loza MI, Domínguez E, Watson SP, García Á. Morán LA, et al. Thromb Haemost. 2022 Aug;122(8):1361-1368. doi: 10.1055/a-1772-1069. Epub 2022 Feb 15. Thromb Haemost. 2022. PMID: 35170009 Free PMC article.
45 results