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Cellular senescence in skin-related research: Targeted signaling pathways and naturally occurring therapeutic agents.
Dańczak-Pazdrowska A, Gornowicz-Porowska J, Polańska A, Krajka-Kuźniak V, Stawny M, Gostyńska A, Rubiś B, Nourredine S, Ashiqueali S, Schneider A, Tchkonia T, Wyles SP, Kirkland JL, Masternak MM. Dańczak-Pazdrowska A, et al. Among authors: kirkland jl. Aging Cell. 2023 Jun;22(6):e13845. doi: 10.1111/acel.13845. Epub 2023 Apr 11. Aging Cell. 2023. PMID: 37042069 Free PMC article. Review.
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: kirkland jl. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. J Clin Invest. 2023. PMID: 36809340 Free PMC article.
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.
Nambiar A, Kellogg D 3rd, Justice J, Goros M, Gelfond J, Pascual R, Hashmi S, Masternak M, Prata L, LeBrasseur N, Limper A, Kritchevsky S, Musi N, Tchkonia T, Kirkland J. Nambiar A, et al. EBioMedicine. 2023 Apr;90:104481. doi: 10.1016/j.ebiom.2023.104481. Epub 2023 Feb 28. EBioMedicine. 2023. PMID: 36857968 Free PMC article. Clinical Trial.
A chronic wound model to investigate skin cellular senescence.
Wyles SP, Dashti P, Pirtskhalava T, Tekin B, Inman C, Gomez LS, Lagnado AB, Prata L, Jurk D, Passos JF, Tchkonia T, Kirkland JL. Wyles SP, et al. Among authors: kirkland jl. Aging (Albany NY). 2023 Apr 21;15(8):2852-2862. doi: 10.18632/aging.204667. Epub 2023 Apr 21. Aging (Albany NY). 2023. PMID: 37086260 Free PMC article.
Mapping cellular senescence networks in human diabetic foot ulcers.
Yu GT, Monie DD, Khosla S, Tchkonia T, Kirkland JL, Wyles SP. Yu GT, et al. Among authors: kirkland jl. Geroscience. 2024 Feb;46(1):1071-1082. doi: 10.1007/s11357-023-00854-x. Epub 2023 Jun 29. Geroscience. 2024. PMID: 37380899 Free PMC article.
Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial.
Justice JN, Leng XI, LeBrasseur NK, Tchkonia T, Kirkland JL, Mitin N, Liu Y, Kritchevsky SB, Nicklas BJ, Ding J. Justice JN, et al. Among authors: kirkland jl. J Gerontol A Biol Sci Med Sci. 2024 Jan 1;79(1):glad214. doi: 10.1093/gerona/glad214. J Gerontol A Biol Sci Med Sci. 2024. PMID: 37738560 Free PMC article. Clinical Trial.
Cellular senescence in brain aging and cognitive decline.
Shafqat A, Khan S, Omer MH, Niaz M, Albalkhi I, AlKattan K, Yaqinuddin A, Tchkonia T, Kirkland JL, Hashmi SK. Shafqat A, et al. Among authors: kirkland jl. Front Aging Neurosci. 2023 Nov 23;15:1281581. doi: 10.3389/fnagi.2023.1281581. eCollection 2023. Front Aging Neurosci. 2023. PMID: 38076538 Free PMC article. Review.
370 results