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Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage.
Zhang B, Phetsang W, Stone MRL, Kc S, Butler MS, Cooper MA, Elliott AG, Łapińska U, Voliotis M, Tsaneva-Atanasova K, Pagliara S, Blaskovich MAT. Zhang B, et al. Among authors: phetsang w. Commun Biol. 2023 Apr 14;6(1):409. doi: 10.1038/s42003-023-04745-x. Commun Biol. 2023. PMID: 37055536 Free PMC article.
Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria.
Blaskovich MAT, Hansford KA, Gong Y, Butler MS, Muldoon C, Huang JX, Ramu S, Silva AB, Cheng M, Kavanagh AM, Ziora Z, Premraj R, Lindahl F, Bradford TA, Lee JC, Karoli T, Pelingon R, Edwards DJ, Amado M, Elliott AG, Phetsang W, Daud NH, Deecke JE, Sidjabat HE, Ramaologa S, Zuegg J, Betley JR, Beevers APG, Smith RAG, Roberts JA, Paterson DL, Cooper MA. Blaskovich MAT, et al. Among authors: phetsang w. Nat Commun. 2018 Jan 2;9(1):22. doi: 10.1038/s41467-017-02123-w. Nat Commun. 2018. PMID: 29295973 Free PMC article.
Fast bacterial growth reduces antibiotic accumulation and efficacy.
Łapińska U, Voliotis M, Lee KK, Campey A, Stone MRL, Tuck B, Phetsang W, Zhang B, Tsaneva-Atanasova K, Blaskovich MAT, Pagliara S. Łapińska U, et al. Among authors: phetsang w. Elife. 2022 Jun 7;11:e74062. doi: 10.7554/eLife.74062. Elife. 2022. PMID: 35670099 Free PMC article.
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
Gallardo-Godoy A, Muldoon C, Becker B, Elliott AG, Lash LH, Huang JX, Butler MS, Pelingon R, Kavanagh AM, Ramu S, Phetsang W, Blaskovich MA, Cooper MA. Gallardo-Godoy A, et al. Among authors: phetsang w. J Med Chem. 2016 Feb 11;59(3):1068-77. doi: 10.1021/acs.jmedchem.5b01593. Epub 2016 Jan 27. J Med Chem. 2016. PMID: 26734854 Free PMC article.
12 results