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The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer.
Kazantseva M, Mehta S, Eiholzer RA, Gimenez G, Bowie S, Campbell H, Reily-Bell AL, Roth I, Ray S, Drummond CJ, Reid G, Joruiz SM, Wiles A, Morrin HR, Reader KL, Hung NA, Baird MA, Slatter TL, Braithwaite AW. Kazantseva M, et al. Cell Death Dis. 2019 Aug 20;10(9):631. doi: 10.1038/s41419-019-1861-1. Cell Death Dis. 2019. PMID: 31431617 Free PMC article.
∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling.
Campbell H, Fleming N, Roth I, Mehta S, Wiles A, Williams G, Vennin C, Arsic N, Parkin A, Pajic M, Munro F, McNoe L, Black M, McCall J, Slatter TL, Timpson P, Reddel R, Roux P, Print C, Baird MA, Braithwaite AW. Campbell H, et al. Nat Commun. 2018 Jan 17;9(1):254. doi: 10.1038/s41467-017-02408-0. Nat Commun. 2018. PMID: 29343721 Free PMC article.
Increased paired box transcription factor 8 has a survival function in glioma.
Hung N, Chen YJ, Taha A, Olivecrona M, Boet R, Wiles A, Warr T, Shaw A, Eiholzer R, Baguley BC, Eccles MR, Braithwaite AW, Macfarlane M, Royds JA, Slatter T. Hung N, et al. BMC Cancer. 2014 Mar 6;14:159. doi: 10.1186/1471-2407-14-159. BMC Cancer. 2014. PMID: 24602166 Free PMC article.
The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival.
Royds JA, Al Nadaf S, Wiles AK, Chen YJ, Ahn A, Shaw A, Bowie S, Lam F, Baguley BC, Braithwaite AW, MacFarlane MR, Hung NA, Slatter TL. Royds JA, et al. Among authors: wiles ak. PLoS One. 2011;6(10):e26737. doi: 10.1371/journal.pone.0026737. Epub 2011 Oct 26. PLoS One. 2011. PMID: 22046342 Free PMC article.
17 results