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FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms.
Ahmed MS, Farag AB, Boys IN, Wang P, Menendez-Montes I, Nguyen NUN, Eitson JL, Ohlson MB, Fan W, McDougal MB, Mar K, Thet S, Ortiz F, Kim SY, Solmonson A, Williams NS, Lemoff A, DeBerardinis RJ, Schoggins JW, Sadek HA. Ahmed MS, et al. Among authors: williams ns. Biomed Pharmacother. 2023 Jun;162:114614. doi: 10.1016/j.biopha.2023.114614. Epub 2023 Mar 28. Biomed Pharmacother. 2023. PMID: 37068330 Free PMC article.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Theodoropoulos PC, et al. Among authors: williams ns. Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1. Nat Chem Biol. 2016. PMID: 26829472 Free PMC article.
MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.
Venkateswaran N, Lafita-Navarro MC, Hao YH, Kilgore JA, Perez-Castro L, Braverman J, Borenstein-Auerbach N, Kim M, Lesner NP, Mishra P, Brabletz T, Shay JW, DeBerardinis RJ, Williams NS, Yilmaz OH, Conacci-Sorrell M. Venkateswaran N, et al. Among authors: williams ns. Genes Dev. 2019 Sep 1;33(17-18):1236-1251. doi: 10.1101/gad.327056.119. Epub 2019 Aug 15. Genes Dev. 2019. PMID: 31416966 Free PMC article.
Atovaquone for treatment of COVID-19: A prospective randomized, double-blind, placebo-controlled clinical trial.
Jain MK, De Lemos JA, McGuire DK, Ayers C, Eitson JL, Sanchez CL, Kamel D, Meisner JA, Thomas EV, Hegde AA, Mocherla S, Strebe JK, Li X, Williams NS, Xing C, Ahmed MS, Wang P, Sadek HA, Schoggins JW. Jain MK, et al. Among authors: williams ns. Front Pharmacol. 2022 Sep 30;13:1020123. doi: 10.3389/fphar.2022.1020123. eCollection 2022. Front Pharmacol. 2022. PMID: 36249792 Free PMC article.
Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
Nguyen TP, Wang W, Sternisha AC, Corley CD, Wang HL, Wang X, Ortiz F, Lim SK, Abdullah KG, Parada LF, Williams NS, McBrayer SK, McDonald JG, De Brabander JK, Nijhawan D. Nguyen TP, et al. Among authors: williams ns. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. doi: 10.1016/j.chembiol.2023.01.005. Epub 2023 Feb 8. Cell Chem Biol. 2023. PMID: 36758549 Free PMC article.
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.
Venkateswaran N, Garcia R, Lafita-Navarro MC, Hao YH, Perez-Castro L, Nogueira PAS, Solmonson A, Mender I, Kilgore JA, Fang S, Brown IN, Li L, Parks E, Lopes Dos Santos I, Bhaskar M, Kim J, Jia Y, Lemoff A, Grishin NV, Kinch L, Xu L, Williams NS, Shay JW, DeBerardinis RJ, Zhu H, Conacci-Sorrell M. Venkateswaran N, et al. Among authors: williams ns. Nat Commun. 2024 May 20;15(1):4266. doi: 10.1038/s41467-024-47868-3. Nat Commun. 2024. PMID: 38769298 Free PMC article.
Targeting calcineurin induces cardiomyocyte proliferation in adult mice.
Lam NT, Nguyen NUN, Ahmed MS, Hsu CC, Rios Coronado PE, Li S, Menendez-Montes I, Thet S, Elhelaly WM, Xiao F, Wang X, Williams NS, Canseco DC, Red-Horse K, Rothermel BA, Sadek HA. Lam NT, et al. Among authors: williams ns. Nat Cardiovasc Res. 2022 Jul;1(7):679-688. doi: 10.1038/s44161-022-00098-6. Epub 2022 Jul 13. Nat Cardiovasc Res. 2022. PMID: 39196243
Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model.
Zang QS, Sadek H, Maass DL, Martinez B, Ma L, Kilgore JA, Williams NS, Frantz DE, Wigginton JG, Nwariaku FE, Wolf SE, Minei JP. Zang QS, et al. Among authors: williams ns. Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1847-59. doi: 10.1152/ajpheart.00203.2011. Epub 2012 Mar 9. Am J Physiol Heart Circ Physiol. 2012. PMID: 22408027 Free article.
420 results