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Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium.
van Wijk RC, Lucía A, Sudhakar PK, Sonnenkalb L, Gaudin C, Hoffmann E, Dremierre B, Aguilar-Ayala DA, Molin MD, Rybniker J, de Giorgi S, Cioetto-Mazzabò L, Segafreddo G, Manganelli R, Degiacomi G, Recchia D, Pasca MR, Simonsson USH, Ramón-García S; ERA4TB consortium. van Wijk RC, et al. Among authors: degiacomi g. iScience. 2023 Mar 15;26(4):106411. doi: 10.1016/j.isci.2023.106411. eCollection 2023 Apr 21. iScience. 2023. PMID: 37091238 Free PMC article.
Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones.
Pasca MR, Degiacomi G, Ribeiro AL, Zara F, De Mori P, Heym B, Mirrione M, Brerra R, Pagani L, Pucillo L, Troupioti P, Makarov V, Cole ST, Riccardi G. Pasca MR, et al. Among authors: degiacomi g. Antimicrob Agents Chemother. 2010 Apr;54(4):1616-8. doi: 10.1128/AAC.01676-09. Epub 2010 Jan 19. Antimicrob Agents Chemother. 2010. PMID: 20086151 Free PMC article.
Antituberculars which target decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1: state of art.
Buroni S, Pasca MR, de Jesus Lopes Ribeiro AL, Degiacomi G, Molteni E, Riccardi G. Buroni S, et al. Among authors: degiacomi g. Appl Microbiol Biotechnol. 2012 May;94(4):907-16. doi: 10.1007/s00253-012-4013-4. Epub 2012 Apr 18. Appl Microbiol Biotechnol. 2012. Retraction in: Appl Microbiol Biotechnol. 2012 Sep;95(5):1369. doi: 10.1007/s00253-012-4217-7 PMID: 22526781 Retracted. Review.
GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.
Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM. Ventura M, et al. Among authors: degiacomi g. Mol Microbiol. 2013 Oct;90(2):356-66. doi: 10.1111/mmi.12368. Epub 2013 Sep 8. Mol Microbiol. 2013. PMID: 23962235 Free article.
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR. Mori G, et al. Among authors: degiacomi g. Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18. Chem Biol. 2015. PMID: 26097035 Free PMC article.
A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.
Esposito M, Szadocka S, Degiacomi G, Orena BS, Mori G, Piano V, Boldrin F, Zemanová J, Huszár S, Barros D, Ekins S, Lelièvre J, Manganelli R, Mattevi A, Pasca MR, Riccardi G, Ballell L, Mikušová K, Chiarelli LR. Esposito M, et al. Among authors: degiacomi g. ACS Infect Dis. 2017 Jun 9;3(6):428-437. doi: 10.1021/acsinfecdis.7b00006. Epub 2017 May 11. ACS Infect Dis. 2017. PMID: 28475832
First triclosan-based macrocyclic inhibitors of InhA enzyme.
Rodriguez F, Saffon N, Sammartino JC, Degiacomi G, Pasca MR, Lherbet C. Rodriguez F, et al. Among authors: degiacomi g. Bioorg Chem. 2020 Jan;95:103498. doi: 10.1016/j.bioorg.2019.103498. Epub 2019 Dec 6. Bioorg Chem. 2020. PMID: 31855823
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug.
Mori G, Orena BS, Chiarelli LR, Degiacomi G, Riabova O, Sammartino JC, Makarov V, Riccardi G, Pasca MR. Mori G, et al. Among authors: degiacomi g. Front Microbiol. 2020 Feb 25;11:292. doi: 10.3389/fmicb.2020.00292. eCollection 2020. Front Microbiol. 2020. PMID: 32158439 Free PMC article.
41 results