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The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells.
Borges da Silva H, Beura LK, Wang H, Hanse EA, Gore R, Scott MC, Walsh DA, Block KE, Fonseca R, Yan Y, Hippen KL, Blazar BR, Masopust D, Kelekar A, Vulchanova L, Hogquist KA, Jameson SC. Borges da Silva H, et al. Among authors: scott mc. Nature. 2018 Jul;559(7713):264-268. doi: 10.1038/s41586-018-0282-0. Epub 2018 Jul 4. Nature. 2018. PMID: 29973721 Free PMC article.
Developmental plasticity allows outside-in immune responses by resident memory T cells.
Fonseca R, Beura LK, Quarnstrom CF, Ghoneim HE, Fan Y, Zebley CC, Scott MC, Fares-Frederickson NJ, Wijeyesinghe S, Thompson EA, Borges da Silva H, Vezys V, Youngblood B, Masopust D. Fonseca R, et al. Among authors: scott mc. Nat Immunol. 2020 Apr;21(4):412-421. doi: 10.1038/s41590-020-0607-7. Epub 2020 Feb 17. Nat Immunol. 2020. PMID: 32066954 Free PMC article.
Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia.
Beura LK, Scott MC, Pierson MJ, Joag V, Wijeyesinghe S, Semler MR, Quarnstrom CF, Busman-Sahay K, Estes JD, Hamilton SE, Vezys V, O'Connor DH, Masopust D. Beura LK, et al. Among authors: scott mc. J Immunol. 2022 Nov 1;209(9):1691-1702. doi: 10.4049/jimmunol.2200320. Epub 2022 Sep 19. J Immunol. 2022. PMID: 36122933 Free PMC article.
Functional T cells are capable of supernumerary cell division and longevity.
Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D. Soerens AG, et al. Among authors: scott mc. Nature. 2023 Feb;614(7949):762-766. doi: 10.1038/s41586-022-05626-9. Epub 2023 Jan 18. Nature. 2023. PMID: 36653453 Free PMC article.
Chronic antigen in solid tumors drives a distinct program of T cell residence.
Gavil NV, Scott MC, Weyu E, Smith OC, O'Flanagan SD, Wijeyesinghe S, Lotfi-Emran S, Shiao SL, Vezys V, Masopust D. Gavil NV, et al. Among authors: scott mc. Sci Immunol. 2023 Jun 8;8(84):eadd5976. doi: 10.1126/sciimmunol.add5976. Epub 2023 Jun 2. Sci Immunol. 2023. PMID: 37267383 Free PMC article.
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence.
Scott MC, Steier Z, Pierson MJ, Stolley JM, O'Flanagan SD, Soerens AG, Wijeyesinghe SP, Beura LK, Dileepan G, Burbach BJ, Künzli M, Quarnstrom CF, Ghirardelli Smith OC, Weyu E, Hamilton SE, Vezys V, Shalek AK, Masopust D. Scott MC, et al. Immunity. 2024 Dec 20:S1074-7613(24)00522-3. doi: 10.1016/j.immuni.2024.11.007. Online ahead of print. Immunity. 2024. PMID: 39708817
188 results