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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Johns DG, Campeau LC, Banka P, Bautmans A, Bueters T, Bianchi E, Branca D, Bulger PG, Crevecoeur I, Ding FX, Garbaccio RM, Guetschow ED, Guo Y, Ha SN, Johnston JM, Josien H, Kauh EA, Koeplinger KA, Kuethe JT, Lai E, Lanning CL, Lee AYH, Li L, Nair AG, O'Neill EA, Stoch SA, Thaisrivongs DA, Tucker TJ, Vachal P, van Dyck K, Vanhoutte FP, Volckaert B, Wolford DG, Xu A, Zhao T, Zhou D, Zhou S, Zhu X, Zokian HJ, Walji AM, Wood HB. Johns DG, et al. Among authors: johnston jm. Circulation. 2023 Jul 11;148(2):144-158. doi: 10.1161/CIRCULATIONAHA.122.063372. Epub 2023 May 1. Circulation. 2023. PMID: 37125593 Free PMC article.
Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, Duggal R, Habulihaz B, Barlock B, Ha S, Sadruddin A, Yeo C, Strickland C, Peier A, Henry B, Sherer EC, Partridge AW. Ng S, et al. Among authors: johnston jm. J Med Chem. 2022 Jul 19. doi: 10.1021/acs.jmedchem.2c00406. Online ahead of print. J Med Chem. 2022. PMID: 35853179
Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology.
Garrigou M, Sauvagnat B, Duggal R, Boo N, Gopal P, Johnston JM, Partridge A, Sawyer T, Biswas K, Boyer N. Garrigou M, et al. Among authors: johnston jm. J Med Chem. 2022 Jul 14;65(13):8961-8974. doi: 10.1021/acs.jmedchem.2c00154. Epub 2022 Jun 15. J Med Chem. 2022. PMID: 35707970 Free PMC article.
Deep Dive into Machine Learning Models for Protein Engineering.
Xu Y, Verma D, Sheridan RP, Liaw A, Ma J, Marshall NM, McIntosh J, Sherer EC, Svetnik V, Johnston JM. Xu Y, et al. Among authors: johnston jm. J Chem Inf Model. 2020 Jun 22;60(6):2773-2790. doi: 10.1021/acs.jcim.0c00073. Epub 2020 May 5. J Chem Inf Model. 2020. PMID: 32250622
A non-canonical mechanism of GPCR activation.
Powers AS, Khan A, Paggi JM, Latorraca NR, Souza S, Di Salvo J, Lu J, Soisson SM, Johnston JM, Weinglass AB, Dror RO. Powers AS, et al. Among authors: johnston jm. Nat Commun. 2024 Nov 16;15(1):9938. doi: 10.1038/s41467-024-54103-6. Nat Commun. 2024. PMID: 39550377 Free PMC article.
Treatment of sleep-disordered breathing among children with myelomeningocele.
Stewart A, Rau S, Shellhaas RA, Woodward J, Hopson B, Arynchyna-Smith A, Shamblin I, Blount JP, Pascoe JE, Rozzelle CJ, Johnston JM, Maddox MH, Rocque BG. Stewart A, et al. Among authors: johnston jm. J Neurosurg Pediatr. 2024 Nov 1:1-5. doi: 10.3171/2024.8.PEDS24223. Online ahead of print. J Neurosurg Pediatr. 2024. PMID: 39486076
Global Partnerships in Neurosurgery: Mapping the Need.
Gupta S, Gomez MG, Johnston JM, Park KB. Gupta S, et al. Among authors: johnston jm. Neurosurg Clin N Am. 2024 Oct;35(4):489-498. doi: 10.1016/j.nec.2024.05.011. Epub 2024 Jul 25. Neurosurg Clin N Am. 2024. PMID: 39244321 Review.
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