Tsai CN - Search Results

1

Inhibiting fatty acid synthesis overcomes colistin resistance.

Carfrae LA, Rachwalski K, French S, Gordzevich R, Seidel L, Tsai CN, Tu MM, MacNair CR, Ovchinnikova OG, Clarke BR, Whitfield C, Brown ED. Carfrae LA, et al. Among authors: tsai cn. Nat Microbiol. 2023 Jun;8(6):1026-1038. doi: 10.1038/s41564-023-01369-z. Epub 2023 May 1. Nat Microbiol. 2023. PMID: 37127701

2

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium.

Ellis MJ, Tsai CN, Johnson JW, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Magolan J, Coombes BK, Brown ED. Ellis MJ, et al. Among authors: tsai cn. Nat Commun. 2019 Jan 14;10(1):197. doi: 10.1038/s41467-018-08190-x. Nat Commun. 2019. PMID: 30643129 Free PMC article.

3

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens.

Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED. Carfrae LA, et al. Among authors: tsai cn. Nat Microbiol. 2020 Jan;5(1):93-101. doi: 10.1038/s41564-019-0595-2. Epub 2019 Oct 28. Nat Microbiol. 2020. PMID: 31659298

4

Creative targeting of the Gram-negative outer membrane in antibiotic discovery.

MacNair CR, Tsai CN, Brown ED. MacNair CR, et al. Among authors: tsai cn. Ann N Y Acad Sci. 2020 Jan;1459(1):69-85. doi: 10.1111/nyas.14280. Epub 2019 Nov 24. Ann N Y Acad Sci. 2020. PMID: 31762048 Review.

5

Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence.

Tsai CN, MacNair CR, Cao MPT, Perry JN, Magolan J, Brown ED, Coombes BK. Tsai CN, et al. Cell Chem Biol. 2020 Jul 16;27(7):793-805.e7. doi: 10.1016/j.chembiol.2020.04.005. Epub 2020 May 14. Cell Chem Biol. 2020. PMID: 32413287 Free article.

6

Emergence of invasive Salmonella in Africa.

Tsai CN, Coombes BK. Tsai CN, et al. Nat Microbiol. 2021 Mar;6(3):273-274. doi: 10.1038/s41564-021-00864-5. Nat Microbiol. 2021. PMID: 33510475 No abstract available.

7

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.

Klobucar K, Jardine E, Farha MA, MacKinnon MR, Fragis M, Nkonge B, Bhando T, Borrillo L, Tsai CN, Johnson JW, Coombes BK, Magolan J, Brown ED. Klobucar K, et al. Among authors: tsai cn. ACS Infect Dis. 2022 Oct 14;8(10):2187-2197. doi: 10.1021/acsinfecdis.2c00357. Epub 2022 Sep 13. ACS Infect Dis. 2022. PMID: 36098580

8

Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal Salmonella (iNTS).

Tsai CN, Massicotte MA, MacNair CR, Perry JN, Brown ED, Coombes BK. Tsai CN, et al. RSC Chem Biol. 2023 Jul 8;4(8):600-612. doi: 10.1039/d3cb00014a. eCollection 2023 Aug 3. RSC Chem Biol. 2023. PMID: 37547457 Free PMC article.

9

Returning to Nature for the Next Generation of Antimicrobial Therapeutics.

MacNair CR, Tsai CN, Rutherford ST, Tan MW. MacNair CR, et al. Among authors: tsai cn. Antibiotics (Basel). 2023 Aug 1;12(8):1267. doi: 10.3390/antibiotics12081267. Antibiotics (Basel). 2023. PMID: 37627687 Free PMC article. Review.

10

Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome.

Ilyas B, Tsai CN, Coombes BK. Ilyas B, et al. Among authors: tsai cn. Front Cell Infect Microbiol. 2017 Sep 29;7:428. doi: 10.3389/fcimb.2017.00428. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 29034217 Free PMC article. Review.

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