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Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
Rasmussen DM, Semonis MM, Greene JT, Muretta JM, Thompson AR, Ramos ST, Thomas DD, Pomerantz WCK, Freedman TS, Levinson NM. Rasmussen DM, et al. Among authors: pomerantz wck. bioRxiv [Preprint]. 2023 Nov 15:2023.04.18.536450. doi: 10.1101/2023.04.18.536450. bioRxiv. 2023. Update in: Elife. 2024 May 14;13:RP95481. doi: 10.7554/eLife.95481 PMID: 37131649 Free PMC article. Updated. Preprint.
Oxidation increases the strength of the methionine-aromatic interaction.
Lewis AK, Dunleavy KM, Senkow TL, Her C, Horn BT, Jersett MA, Mahling R, McCarthy MR, Perell GT, Valley CC, Karim CB, Gao J, Pomerantz WC, Thomas DD, Cembran A, Hinderliter A, Sachs JN. Lewis AK, et al. Nat Chem Biol. 2016 Oct;12(10):860-6. doi: 10.1038/nchembio.2159. Epub 2016 Aug 22. Nat Chem Biol. 2016. PMID: 27547920 Free PMC article.
Soluble Methane Monooxygenase Component Interactions Monitored by 19F NMR.
Jones JC, Banerjee R, Shi K, Semonis MM, Aihara H, Pomerantz WCK, Lipscomb JD. Jones JC, et al. Among authors: pomerantz wck. Biochemistry. 2021 Jun 29;60(25):1995-2010. doi: 10.1021/acs.biochem.1c00293. Epub 2021 Jun 8. Biochemistry. 2021. PMID: 34100595 Free PMC article.
Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors.
Buchholz CR, Sneddon MS, McPherson JE, Das S, Gee CT, Grillo MJ, Chai SC, Lee RE, Chen T, Harki DA, Shelat AA, Pomerantz WCK. Buchholz CR, et al. Among authors: pomerantz wck. ACS Med Chem Lett. 2023 Oct 3;14(10):1441-1447. doi: 10.1021/acsmedchemlett.3c00343. eCollection 2023 Oct 12. ACS Med Chem Lett. 2023. PMID: 37849548 Free PMC article.
Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.
Divakaran A, Scholtz CR, Zahid H, Lin W, Griffith EC, Lee RE, Chen T, Harki DA, Pomerantz WCK. Divakaran A, et al. Among authors: pomerantz wck. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627. doi: 10.1021/acsmedchemlett.2c00300. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262390 Free PMC article.
75 results