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Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion.
Carroll DT, Elsakr JM, Miller A, Fuhr J, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M. Carroll DT, et al. Among authors: aagaard km. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E577-E588. doi: 10.1152/ajpendo.00087.2023. Epub 2023 May 3. Am J Physiol Endocrinol Metab. 2023. PMID: 37134140 Free PMC article.
Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques.
McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. McCurdy CE, et al. Among authors: aagaard km. JCI Insight. 2016 Oct 6;1(16):e86612. doi: 10.1172/jci.insight.86612. JCI Insight. 2016. PMID: 27734025 Free PMC article.
A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes.
Barbour LA, Scifres C, Valent AM, Friedman JE, Buchanan TA, Coustan D, Aagaard K, Thornburg KL, Catalano PM, Galan HL, Hay WW Jr, Frias AE, Shankar K, Simmons RA, Moses RG, Sacks DA, Loeken MR. Barbour LA, et al. Am J Obstet Gynecol. 2018 Oct;219(4):367.e1-367.e7. doi: 10.1016/j.ajog.2018.06.013. Epub 2018 Jun 28. Am J Obstet Gynecol. 2018. PMID: 29959933 Free PMC article.
Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.
Seferovic MD, Beamish CA, Mosser RE, Townsend SE, Pappan K, Poitout V, Aagaard KM, Gannon M. Seferovic MD, et al. Among authors: aagaard km. Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1251-E1263. doi: 10.1152/ajpendo.00001.2018. Epub 2018 Aug 14. Am J Physiol Endocrinol Metab. 2018. PMID: 30106624 Free PMC article.
Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.
Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Wesolowski SR, et al. Among authors: aagaard km. Mol Metab. 2018 Dec;18:25-41. doi: 10.1016/j.molmet.2018.09.008. Epub 2018 Sep 28. Mol Metab. 2018. PMID: 30337225 Free PMC article.
Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition.
Elsakr JM, Dunn JC, Tennant K, Zhao SK, Kroeten K, Pasek RC, Takahashi DL, Dean TA, Velez Edwards DR, McCurdy CE, Aagaard KM, Powers AC, Friedman JE, Kievit P, Gannon M. Elsakr JM, et al. Among authors: aagaard km. Mol Metab. 2019 Jul;25:73-82. doi: 10.1016/j.molmet.2019.03.010. Epub 2019 Apr 12. Mol Metab. 2019. PMID: 31036449 Free PMC article.
193 results