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Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states.
Al-Dalahmah O, Argenziano MG, Kannan A, Mahajan A, Furnari J, Paryani F, Boyett D, Save A, Humala N, Khan F, Li J, Lu H, Sun Y, Tuddenham JF, Goldberg AR, Dovas A, Banu MA, Sudhakar T, Bush E, Lassman AB, McKhann GM, Gill BJA, Youngerman B, Sisti MB, Bruce JN, Sims PA, Menon V, Canoll P. Al-Dalahmah O, et al. Among authors: menon v. Nat Commun. 2023 May 4;14(1):2586. doi: 10.1038/s41467-023-38186-1. Nat Commun. 2023. PMID: 37142563 Free PMC article.
Single-nucleus RNA-seq identifies Huntington disease astrocyte states.
Al-Dalahmah O, Sosunov AA, Shaik A, Ofori K, Liu Y, Vonsattel JP, Adorjan I, Menon V, Goldman JE. Al-Dalahmah O, et al. Among authors: menon v. Acta Neuropathol Commun. 2020 Feb 18;8(1):19. doi: 10.1186/s40478-020-0880-6. Acta Neuropathol Commun. 2020. PMID: 32070434 Free PMC article.
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Olah M, Menon V, Habib N, Taga MF, Ma Y, Yung CJ, Cimpean M, Khairallah A, Coronas-Samano G, Sankowski R, Grün D, Kroshilina AA, Dionne D, Sarkis RA, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Prinz M, Vonsattel JPG, Teich AF, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL. Olah M, et al. Among authors: menon v. Nat Commun. 2020 Nov 30;11(1):6129. doi: 10.1038/s41467-020-19737-2. Nat Commun. 2020. PMID: 33257666 Free PMC article.
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.
Lim RG, Al-Dalahmah O, Wu J, Gold MP, Reidling JC, Tang G, Adam M, Dansu DK, Park HJ, Casaccia P, Miramontes R, Reyes-Ortiz AM, Lau A, Hickman RA, Khan F, Paryani F, Tang A, Ofori K, Miyoshi E, Michael N, McClure N, Flowers XE, Vonsattel JP, Davidson S, Menon V, Swarup V, Fraenkel E, Goldman JE, Thompson LM. Lim RG, et al. Among authors: menon v. Nat Commun. 2022 Dec 21;13(1):7791. doi: 10.1038/s41467-022-35388-x. Nat Commun. 2022. PMID: 36543778 Free PMC article.
INPP5D regulates inflammasome activation in human microglia.
Chou V, Pearse RV 2nd, Aylward AJ, Ashour N, Taga M, Terzioglu G, Fujita M, Fancher SB, Sigalov A, Benoit CR, Lee H, Lam M, Seyfried NT, Bennett DA, De Jager PL, Menon V, Young-Pearse TL. Chou V, et al. Among authors: menon v. Nat Commun. 2023 Nov 29;14(1):7552. doi: 10.1038/s41467-023-42819-w. Nat Commun. 2023. PMID: 38016942 Free PMC article.
A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.
Haage V, Tuddenham JF, Comandante-Lou N, Bautista A, Monzel A, Chiu R, Fujita M, Garcia FG, Bhattarai P, Patel R, Buonfiglioli A, Idiarte J, Herman M, Rinderspacher A, Mela A, Zhao W, Argenziano MG, Furnari JL, Banu MA, Landry DW, Bruce JN, Canoll P, Zhang Y, Nuriel T, Kizil C, Sproul AA, de Witte LD, Sims PA, Menon V, Picard M, De Jager PL. Haage V, et al. Among authors: menon v. bioRxiv [Preprint]. 2024 Feb 6:2024.02.06.579103. doi: 10.1101/2024.02.06.579103. bioRxiv. 2024. PMID: 38370689 Free PMC article. Preprint.
Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.
Qu W, Lam M, McInvale JJ, Mares JA, Kwon S, Humala N, Mahajan A, Nguyen T, Jakubiak KA, Mun JY, Tedesco TG, Al-Dalahmah O, Hussaini SA, Sproul AA, Siegelin MD, De Jager PL, Canoll P, Menon V, Hargus G. Qu W, et al. Among authors: menon v. Acta Neuropathol. 2024 Jun 25;147(1):107. doi: 10.1007/s00401-024-02755-5. Acta Neuropathol. 2024. PMID: 38918213 Free PMC article.
1,999 results