Zhang Q - Search Results

1

Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects.

Li Y, Si R, Wang J, Hai P, Zheng Y, Zhang Q, Pan X, Zhang J. Li Y, et al. Among authors: zhang q, zhang j. Bioorg Chem. 2023 Aug;137:106575. doi: 10.1016/j.bioorg.2023.106575. Epub 2023 Apr 26. Bioorg Chem. 2023. PMID: 37148706

2

Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol.

Pan X, Liang L, Si R, Wang J, Zhang Q, Zhou H, Zhang L, Zhang J. Pan X, et al. Among authors: zhang l, zhang q, zhang j. Eur J Med Chem. 2019 Feb 1;163:1-9. doi: 10.1016/j.ejmech.2018.11.042. Epub 2018 Nov 22. Eur J Med Chem. 2019. PMID: 30503935

3

Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs.

Shan Y, Si R, Wang J, Zhang Q, Zhou H, Song J, Zhang J, Chen Q. Shan Y, et al. Among authors: zhang q, zhang j. Eur J Med Chem. 2019 Feb 15;164:440-447. doi: 10.1016/j.ejmech.2018.12.067. Epub 2018 Dec 28. Eur J Med Chem. 2019. PMID: 30616052

4

Discovery of novel Bcr-Abl^T315I inhibitors with flexible linker. Part 1: Confirmation optimization of phenyl-1H-indazol-3-amine as hinge binding moiety.

Pan X, Liang L, Sun Y, Si R, Zhang Q, Wang J, Fu J, Zhang J, Zhang J. Pan X, et al. Among authors: zhang q, zhang j. Eur J Med Chem. 2019 Sep 15;178:232-242. doi: 10.1016/j.ejmech.2019.05.091. Epub 2019 Jun 3. Eur J Med Chem. 2019. PMID: 31185413

5

Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization.

Shan Y, Si R, Wang J, Zhang Q, Li J, Ma Y, Zhang J. Shan Y, et al. Among authors: zhang q, zhang j. Eur J Med Chem. 2020 Nov 1;205:112654. doi: 10.1016/j.ejmech.2020.112654. Epub 2020 Jul 23. Eur J Med Chem. 2020. PMID: 32750566

6

Exploring the potential intracellular targets of vascular normalization based on active candidates.

Shan Y, Wang J, Si R, Ma Y, Li J, Zhang Q, Lu W, Zhang J. Shan Y, et al. Among authors: zhang q, zhang j. Bioorg Chem. 2021 Mar;108:104551. doi: 10.1016/j.bioorg.2020.104551. Epub 2020 Dec 15. Bioorg Chem. 2021. PMID: 33353807

7

Effective and transient mapping of protein-protein interactions: Application of novel releasable photoaffinity linkers.

Wang J, Ma Y, Li J, Zhang Q, Pan X, Lu W, Zhang J. Wang J, et al. Among authors: zhang q, zhang j. Drug Dev Res. 2022 Apr;83(2):368-378. doi: 10.1002/ddr.21866. Epub 2021 Aug 23. Drug Dev Res. 2022. PMID: 34424555

8

The Application of Prodrug-based Drug Delivery Strategy in Anticancer Drugs.

Liu N, Chen Q, Zhang Q, Wang J, Si R, Zhang J, Pan X. Liu N, et al. Among authors: zhang q, zhang j. Curr Top Med Chem. 2021;21(24):2184-2204. doi: 10.2174/1568026621666210909163108. Curr Top Med Chem. 2021. PMID: 34503405 Review.

9

Design, synthesis, and biological evaluation of novel Bcr-Abl^T315I inhibitors incorporating amino acids as flexible linker.

Pan X, Liu N, Zhang Q, Wang K, Li Y, Shan Y, Li Z, Zhang J. Pan X, et al. Among authors: zhang q, zhang j. Bioorg Med Chem. 2021 Oct 15;48:116398. doi: 10.1016/j.bmc.2021.116398. Epub 2021 Sep 8. Bioorg Med Chem. 2021. PMID: 34547714

10

Tumor-microenvironmental-response Bi-functional molecules for efficient imaging and anti-tumor activity therapy.

Wang J, Si R, Zhang Q, Pan X, Zhang J. Wang J, et al. Among authors: zhang q, zhang j. Eur J Med Chem. 2022 Feb 15;230:114120. doi: 10.1016/j.ejmech.2022.114120. Epub 2022 Jan 12. Eur J Med Chem. 2022. PMID: 35051748

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