Chang X - Search Results

1

Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer.

Chang X, Zhang D, Qu F, Xie Y, Chen T, Zhang Y, Du Q, Bian J, Li Z, Wang J, Xu X. Chang X, et al. Eur J Med Chem. 2023 Sep 5;257:115490. doi: 10.1016/j.ejmech.2023.115490. Epub 2023 May 18. Eur J Med Chem. 2023. PMID: 37209451

2

Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles.

Xu X, Chang X, Huang J, Zhang D, Wang M, Jing T, Zhuang Y, Kou J, Qiu Z, Wang J, Li Z, Bian J. Xu X, et al. Among authors: chang x. Eur J Med Chem. 2022 Jun 5;236:114337. doi: 10.1016/j.ejmech.2022.114337. Epub 2022 Apr 6. Eur J Med Chem. 2022. PMID: 35428013

3

Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group.

Chang X, Wang M, Zhang D, Zhang Y, Wang J, Li Z, Bian J, Xu X. Chang X, et al. Eur J Med Chem. 2023 Jan 15;246:115014. doi: 10.1016/j.ejmech.2022.115014. Epub 2022 Dec 12. Eur J Med Chem. 2023. PMID: 36525694

4

Enhancing the affinity of novel GLS1 allosteric inhibitors by targeting key residue Lys320.

Zhu L, Chang X, Zhang S, Bai X, Finko AV, Xu X, Bian J, Liu X, Huang H. Zhu L, et al. Among authors: chang x. Future Med Chem. 2023 Aug;15(15):1393-1414. doi: 10.4155/fmc-2023-0114. Epub 2023 Aug 23. Future Med Chem. 2023. PMID: 37610850

5

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective.

Chang X, Qu F, Li C, Zhang J, Zhang Y, Xie Y, Fan Z, Bian J, Wang J, Li Z, Xu X. Chang X, et al. Med Res Rev. 2024 Jul;44(4):1727-1767. doi: 10.1002/med.22024. Epub 2024 Feb 5. Med Res Rev. 2024. PMID: 38314926

6

Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions.

Tong C, Chang X, Qu F, Bian J, Wang J, Li Z, Xu X. Tong C, et al. Among authors: chang x. Eur J Med Chem. 2024 Mar 5;267:116212. doi: 10.1016/j.ejmech.2024.116212. Epub 2024 Feb 10. Eur J Med Chem. 2024. PMID: 38359536 Review.

7

Anti-neuroinflammatory and Neuroprotective Effects of T-006 on Alzheimer's Disease Models by Modulating TLR4-Mediated MyD88/ NF-κB Signaling.

Chen H, Chang X, Zhou J, Zhang G, Cheng J, Zhang Z, Xing J, Yan C, Liu Z. Chen H, et al. Among authors: chang x. CNS Neurol Disord Drug Targets. 2025 Jan 8. doi: 10.2174/0118715273337232241121113048. Online ahead of print. CNS Neurol Disord Drug Targets. 2025. PMID: 39791155

8

Olanzapine exposure disordered lipid metabolism, gut microbiota and behavior in zebrafish (Danio rerio).

Wang Y, You F, Huang Z, Liu Y, Yang B, Chang X, Yang G, Tian X, Feng S, Meng X. Wang Y, et al. Among authors: chang x. Comp Biochem Physiol C Toxicol Pharmacol. 2025 Jan 7:110120. doi: 10.1016/j.cbpc.2025.110120. Online ahead of print. Comp Biochem Physiol C Toxicol Pharmacol. 2025. PMID: 39788356

9

Surgical Experience and Outcome Evaluation of Genital Gender Affirmation Surgery for Transgender Female in China: A Case Series.

Wang G, Chang X, Yang X, Zhao R, Qian J, Liu Y, Xing Q, Pan B. Wang G, et al. Among authors: chang x. Aesthetic Plast Surg. 2025 Jan 8. doi: 10.1007/s00266-024-04628-4. Online ahead of print. Aesthetic Plast Surg. 2025. PMID: 39779504

10

Defining serine tRNA knockout as a strategy for effective repression of gene expression in organisms with a recoded genome.

Voorhees PJ, Chang X, Lai SK. Voorhees PJ, et al. Among authors: chang x. Nucleic Acids Res. 2025 Jan 7;53(1):gkae1266. doi: 10.1093/nar/gkae1266. Nucleic Acids Res. 2025. PMID: 39777459 Free PMC article.

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