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Page 1
Structure-activity relationship of dihydropyridines for rhabdomyosarcoma.
Chauhan S, Woods AD, Bharathy N, Lian X, Ricker CA, Mantz A, Zuercher WJ, Price LH, Morton MJ, Durrant E, Corbel SY, Sampath SC, Sampath SC, Joslin J, Keller C. Chauhan S, et al. Among authors: zuercher wj. Biochem Biophys Res Commun. 2023 Jul 30;667:138-145. doi: 10.1016/j.bbrc.2023.04.114. Epub 2023 May 6. Biochem Biophys Res Commun. 2023. PMID: 37224633
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.
Carling PJ, Ryan BJ, McGuinness W, Kataria S, Humble SW, Milde S, Duce JA, Kapadia N, Zuercher WJ, Davis JB, Di Daniel E, Wade-Martins R. Carling PJ, et al. Among authors: zuercher wj. Autophagy. 2023 Feb;19(2):692-705. doi: 10.1080/15548627.2022.2095834. Epub 2022 Jul 25. Autophagy. 2023. PMID: 35786165 Free PMC article.
Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas.
Tiek DM, Erdogdu B, Razaghi R, Jin L, Sadowski N, Alamillo-Ferrer C, Hogg JR, Haddad BR, Drewry DH, Wells CI, Pickett JE, Song X, Goenka A, Hu B, Goldlust SA, Zuercher WJ, Pertea M, Timp W, Cheng SY, Riggins RB. Tiek DM, et al. Among authors: zuercher wj. Sci Adv. 2022 Jun 24;8(25):eabn3471. doi: 10.1126/sciadv.abn3471. Epub 2022 Jun 22. Sci Adv. 2022. PMID: 35731869 Free PMC article.
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Serafim RAM, Sorrell FJ, Berger BT, Collins RJ, Vasconcelos SNS, Massirer KB, Knapp S, Bennett J, Fedorov O, Patel H, Zuercher WJ, Elkins JM. Serafim RAM, et al. Among authors: zuercher wj. J Med Chem. 2021 Sep 23;64(18):13259-13278. doi: 10.1021/acs.jmedchem.0c01579. Epub 2021 Aug 31. J Med Chem. 2021. PMID: 34463505
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
Eduful BJ, O'Byrne SN, Temme L, Asquith CRM, Liang Y, Picado A, Pilotte JR, Hossain MA, Wells CI, Zuercher WJ, Catta-Preta CMC, Zonzini Ramos P, Santiago AS, Couñago RM, Langendorf CG, Nay K, Oakhill JS, Pulliam TL, Lin C, Awad D, Willson TM, Frigo DE, Scott JW, Drewry DH. Eduful BJ, et al. Among authors: zuercher wj. J Med Chem. 2021 Aug 12;64(15):10849-10877. doi: 10.1021/acs.jmedchem.0c02274. Epub 2021 Jul 15. J Med Chem. 2021. PMID: 34264658 Free PMC article.
NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
Matossian MD, Elliott S, Van Hoang T, Burks HE, Wright MK, Alzoubi MS, Yan T, Chang T, Wathieu H, Windsor GO, Hartono AB, Lee S, Zuercher WJ, Drewry DH, Wells C, Kapadia N, Buechlein A, Fang F, Nephew KP, Collins-Burow BM, Burow ME. Matossian MD, et al. Among authors: zuercher wj. Breast Cancer Res Treat. 2021 Aug;189(1):49-61. doi: 10.1007/s10549-021-06295-4. Epub 2021 Jul 1. Breast Cancer Res Treat. 2021. PMID: 34196902
89 results