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Thiazole derivatives as dual inhibitors of deoxyribonuclease I and 5-lipoxygenase: A promising scaffold for the development of neuroprotective drugs.
Marković A, Živković A, Atanasova M, Doytchinova I, Hofmann B, George S, Kretschmer S, Rödl C, Steinhilber D, Stark H, Šmelcerović A. Marković A, et al. Among authors: george s. Chem Biol Interact. 2023 Aug 25;381:110542. doi: 10.1016/j.cbi.2023.110542. Epub 2023 May 22. Chem Biol Interact. 2023. PMID: 37224992
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.
Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ. Steinbrink SD, et al. Among authors: george s. Cell Mol Life Sci. 2010 Mar;67(5):797-806. doi: 10.1007/s00018-009-0206-0. Epub 2009 Nov 29. Cell Mol Life Sci. 2010. PMID: 20091083 Free PMC article.
Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.
Hörnig M, Markoutsa S, Häfner AK, George S, Wisniewska JM, Rödl CB, Hofmann B, Maier T, Karas M, Werz O, Steinhilber D. Hörnig M, et al. Among authors: george s. Biochim Biophys Acta. 2012 Feb;1821(2):279-86. doi: 10.1016/j.bbalip.2011.11.001. Epub 2011 Nov 23. Biochim Biophys Acta. 2012. PMID: 22137889
CarbORev-5901: The First Carborane-Based Inhibitor of the 5-Lipoxygenase Pathway.
Kuhnert R, Sárosi MB, George S, Lönnecke P, Hofmann B, Steinhilber D, Murganic B, Mijatovic S, Maksimovic-Ivanic D, Hey-Hawkins E. Kuhnert R, et al. Among authors: george s. ChemMedChem. 2017 Jul 6;12(13):1081-1086. doi: 10.1002/cmdc.201700309. Epub 2017 Jun 21. ChemMedChem. 2017. PMID: 28569429
5,266 results