Sacaan A - Search Results

1

Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.

Yenerall P, Sung T, Palyada K, Qian J, Arat S, Kumpf SW, Wang SW, Biddle K, Esparza C, Chang S, Scott W, Collette W, Winrow TS, Affolter T, Shirai N, Thibault S, Wang J, Liu L, Bauchmann M, Frey J, Steyn S, Sacaan A, Vitsky A, Ahn Y, Paul T, Lum L, Oyer J, Yang A, Hu W. Yenerall P, et al. Among authors: sacaan a. Toxicol Sci. 2023 Jun 28;194(1):53-69. doi: 10.1093/toxsci/kfad049. Toxicol Sci. 2023. PMID: 37228089 Free PMC article.

2

Gemtuzumab Ozogamicin Treatment Results in Decreased Proliferation and Differentiation of Human Megakaryocytes but Does Not Inhibit Mature Platelet Function.

Vitsky A, Sacaan A, Hu W, Finkelstein M, Reagan W. Vitsky A, et al. Among authors: sacaan a. Toxicol Pathol. 2022 Oct;50(7):871-880. doi: 10.1177/01926233221129202. Epub 2022 Oct 6. Toxicol Pathol. 2022. PMID: 36200575

3

Non-clinical combination toxicology studies: strategy, examples and future perspective.

Sacaan A, Hashida SN, Khan NK. Sacaan A, et al. J Toxicol Sci. 2020;45(7):365-371. doi: 10.2131/jts.45.365. J Toxicol Sci. 2020. PMID: 32612005 Free article. Review.

4

Central nervous system tumors in 2-year rat carcinogenicity studies: perspectives on human risk assessment.

Sacaan A, Thibault S, Khan KN. Sacaan A, et al. J Toxicol Sci. 2019;44(10):643-655. doi: 10.2131/jts.44.643. J Toxicol Sci. 2019. PMID: 31588056 Free article. Review.

5

Reproductive and developmental toxicity assessment of palbociclib, a CDK4/6 inhibitor, in Sprague-Dawley rats and New Zealand White rabbits.

Catlin NR, Bowman CJ, Engel SM, Sacaan A, Thibault S, Lewis EM, Cappon GD. Catlin NR, et al. Among authors: sacaan a. Reprod Toxicol. 2019 Sep;88:76-84. doi: 10.1016/j.reprotox.2019.07.016. Epub 2019 Jul 27. Reprod Toxicol. 2019. PMID: 31362042

6

Pharmaceutical industry perspective on combination toxicity studies: Results from an intra-industry survey conducted by IQ DruSafe Leadership Group.

Birkebak J, Buckley LA, Dambach D, Musvasva E, Price K, Ralston S, Sacaan A. Birkebak J, et al. Among authors: sacaan a. Regul Toxicol Pharmacol. 2019 Mar;102:40-46. doi: 10.1016/j.yrtph.2018.12.012. Epub 2018 Dec 19. Regul Toxicol Pharmacol. 2019. PMID: 30576687 Free article.

7

Intestinal Toxicity in Rats Following Administration of CDK4/6 Inhibitors Is Independent of Primary Pharmacology.

Thibault S, Hu W, Hirakawa B, Kalabat D, Franks T, Sung T, Khoh-Reiter S, Lu S, Finkelstein M, Jessen B, Sacaan A. Thibault S, et al. Among authors: sacaan a. Mol Cancer Ther. 2019 Feb;18(2):257-266. doi: 10.1158/1535-7163.MCT-18-0734. Epub 2018 Nov 6. Mol Cancer Ther. 2019. PMID: 30401694

8

CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats.

Sacaan AI, Thibault S, Hong M, Kondegowda NG, Nichols T, Li R, Rosselot C, Evering W, Fenutria R, Vitsky A, Brown T, Finkelstein M, Garcia-Ocaña A, Khan N, Stewart AF, Vasavada RC. Sacaan AI, et al. Mol Cancer Res. 2017 Nov;15(11):1531-1541. doi: 10.1158/1541-7786.MCR-17-0172. Epub 2017 Jul 31. Mol Cancer Res. 2017. PMID: 28760782 Free article.

9

Mechanistic Investigation of Bone Marrow Suppression Associated with Palbociclib and its Differentiation from Cytotoxic Chemotherapies.

Hu W, Sung T, Jessen BA, Thibault S, Finkelstein MB, Khan NK, Sacaan AI. Hu W, et al. Among authors: sacaan ai. Clin Cancer Res. 2016 Apr 15;22(8):2000-8. doi: 10.1158/1078-0432.CCR-15-1421. Epub 2015 Dec 2. Clin Cancer Res. 2016. PMID: 26631614

10

Application of electroretinography (ERG) in early drug development for assessing retinal toxicity in rats.

Huang W, Collette W 3rd, Twamley M, Aguirre SA, Sacaan A. Huang W, et al. Among authors: sacaan a. Toxicol Appl Pharmacol. 2015 Dec 15;289(3):525-33. doi: 10.1016/j.taap.2015.10.008. Epub 2015 Oct 19. Toxicol Appl Pharmacol. 2015. PMID: 26482841

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