Feng Z - Search Results

1

Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases.

Feng Z, Xiang J, Sun G, Liu H, Wang Y, Liu X, Feng J, Xu Q, Wen X, Yuan H, Sun H, Dai L. Feng Z, et al. Among authors: feng j. J Med Chem. 2023 Jun 8;66(11):7331-7354. doi: 10.1021/acs.jmedchem.2c02123. Epub 2023 May 27. J Med Chem. 2023. PMID: 37243609

2

Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors.

Li EQ, Zhao W, Zhang C, Qin LZ, Liu SJ, Feng ZQ, Wen X, Chen CP. Li EQ, et al. Eur J Pharm Sci. 2019 Sep 1;137:105010. doi: 10.1016/j.ejps.2019.105010. Epub 2019 Jul 17. Eur J Pharm Sci. 2019. PMID: 31325544

3

Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression.

Chen CP, Chen K, Feng Z, Wen X, Sun H. Chen CP, et al. Among authors: feng z. Acta Pharm Sin B. 2019 Sep;9(5):937-951. doi: 10.1016/j.apsb.2019.05.001. Epub 2019 May 23. Acta Pharm Sin B. 2019. PMID: 31649844 Free PMC article.

4

Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation.

Dai L, Feng Z, Zha R, Cheng K, Wen X, Sun H, Yuan H. Dai L, et al. Among authors: feng z. J Chem Inf Model. 2020 Mar 23;60(3):1717-1727. doi: 10.1021/acs.jcim.9b00838. Epub 2020 Feb 20. J Chem Inf Model. 2020. PMID: 32027126

5

Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.

Feng Z, Xiang J, Liu H, Li J, Xu X, Sun G, Zheng R, Zhang S, Liu J, Yang S, Xu Q, Wen X, Yuan H, Sun H, Dai L. Feng Z, et al. J Med Chem. 2022 Feb 10;65(3):2571-2592. doi: 10.1021/acs.jmedchem.1c02002. Epub 2022 Jan 21. J Med Chem. 2022. PMID: 35060744

6

Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.

Qian M, Feng ZQ, Zheng RN, Hu KW, Sun JZ, Sun HB, Dai L. Qian M, et al. Chin J Nat Med. 2022 Jun;20(6):432-442. doi: 10.1016/S1875-5364(22)60156-0. Chin J Nat Med. 2022. PMID: 35750383

7

Discovery of novel AdipoRon analogues as potent anti-inflammatory agents against nonalcoholic steatohepatitis.

Dai L, Wang Q, Wang P, Zhang S, Tai L, Xu X, Sun G, Duan M, Yuan H, Feng Z. Dai L, et al. Among authors: feng z. Eur J Med Chem. 2022 Dec 15;244:114800. doi: 10.1016/j.ejmech.2022.114800. Epub 2022 Sep 30. Eur J Med Chem. 2022. PMID: 36215862

8

Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent In Vivo Anti-tumor Immune Activity.

Liu L, Zhang H, Hou J, Zhang Y, Wang L, Wang S, Yao Z, Xie T, Wen X, Xu Q, Dai L, Feng Z, Zhang P, Wu Y, Sun H, Liu J, Yuan H. Liu L, et al. Among authors: feng z. J Med Chem. 2024 Mar 28;67(6):4977-4997. doi: 10.1021/acs.jmedchem.4c00102. Epub 2024 Mar 11. J Med Chem. 2024. PMID: 38465588

9

Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis.

Sun G, Feng Z, Kuang Y, Fu Z, Wang Y, Zhao X, Wang F, Sun H, Yuan H, Dai L. Sun G, et al. Among authors: feng z. Eur J Med Chem. 2024 Apr 5;269:116344. doi: 10.1016/j.ejmech.2024.116344. Epub 2024 Mar 20. Eur J Med Chem. 2024. PMID: 38522113

10

Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases.

Fu Z, Liu X, Yu W, Kuang Y, Wang F, Qian Z, Xu Q, Dai L, Feng Z. Fu Z, et al. Among authors: feng z. Eur J Med Chem. 2025 Jan 15;286:117284. doi: 10.1016/j.ejmech.2025.117284. Online ahead of print. Eur J Med Chem. 2025. PMID: 39827490

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