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The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K).
RSC Med Chem. 2023 Aug 23;14(10):2035-2047. doi: 10.1039/d3md00355h. eCollection 2023 Oct 18.
RSC Med Chem. 2023.
PMID: 37859710
Free PMC article.
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.
Willems HMG, Edwards S, Boffey HK, Chawner SJ, Green C, Romero T, Winpenny D, Skidmore J, Clarke JH, Andrews SP.
Willems HMG, et al. Among authors: boffey hk.
RSC Med Chem. 2023 Apr 17;14(5):934-946. doi: 10.1039/d3md00039g. eCollection 2023 May 25.
RSC Med Chem. 2023.
PMID: 37252102
Free PMC article.
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The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.
Rooney TPC, Aldred GG, Boffey HK, Willems HMG, Edwards S, Chawner SJ, Scott DE, Green C, Winpenny D, Skidmore J, Clarke JH, Andrews SP.
Rooney TPC, et al. Among authors: boffey hk.
J Med Chem. 2023 Jan 12;66(1):804-821. doi: 10.1021/acs.jmedchem.2c01693. Epub 2022 Dec 14.
J Med Chem. 2023.
PMID: 36516442
Free PMC article.
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Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Boffey HK, Rooney TPC, Willems HMG, Edwards S, Green C, Howard T, Ogg D, Romero T, Scott DE, Winpenny D, Duce J, Skidmore J, Clarke JH, Andrews SP.
Boffey HK, et al.
J Med Chem. 2022 Feb 24;65(4):3359-3370. doi: 10.1021/acs.jmedchem.1c01819. Epub 2022 Feb 11.
J Med Chem. 2022.
PMID: 35148092
Free PMC article.
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