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A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
Kenanova DN, Visser EJ, Virta JM, Sijbesma E, Centorrino F, Vickery HR, Zhong M, Neitz RJ, Brunsveld L, Ottmann C, Arkin MR. Kenanova DN, et al. Among authors: arkin mr. ACS Cent Sci. 2023 Apr 18;9(5):937-946. doi: 10.1021/acscentsci.2c01449. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252362 Free PMC article.
Bringing together the academic drug discovery community.
Slusher BS, Conn PJ, Frye S, Glicksman M, Arkin M. Slusher BS, et al. Nat Rev Drug Discov. 2013 Nov;12(11):811-2. doi: 10.1038/nrd4155. Nat Rev Drug Discov. 2013. PMID: 24172316 Free PMC article.
Two approaches to discovering and developing new drugs for Chagas disease.
McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. McKerrow JH, et al. Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1(0 1):263-9. doi: 10.1590/s0074-02762009000900034. Mem Inst Oswaldo Cruz. 2009. PMID: 19753483 Free PMC article.
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Ravalin M, et al. Nat Chem Biol. 2019 Aug;15(8):786-794. doi: 10.1038/s41589-019-0322-6. Epub 2019 Jul 18. Nat Chem Biol. 2019. PMID: 31320752 Free PMC article.
Novel cruzain inhibitors for the treatment of Chagas' disease.
Rogers KE, Keränen H, Durrant JD, Ratnam J, Doak A, Arkin MR, McCammon JA. Rogers KE, et al. Among authors: arkin mr. Chem Biol Drug Des. 2012 Sep;80(3):398-405. doi: 10.1111/j.1747-0285.2012.01416.x. Epub 2012 Jun 27. Chem Biol Drug Des. 2012. PMID: 22613098 Free PMC article.
143 results