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A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
Kenanova DN, Visser EJ, Virta JM, Sijbesma E, Centorrino F, Vickery HR, Zhong M, Neitz RJ, Brunsveld L, Ottmann C, Arkin MR. Kenanova DN, et al. Among authors: sijbesma e. ACS Cent Sci. 2023 Apr 18;9(5):937-946. doi: 10.1021/acscentsci.2c01449. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252362 Free PMC article.
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.
Sijbesma E, Hallenbeck KK, Andrei SA, Rust RR, Adriaans JMC, Brunsveld L, Arkin MR, Ottmann C. Sijbesma E, et al. ACS Med Chem Lett. 2021 May 10;12(6):976-982. doi: 10.1021/acsmedchemlett.1c00088. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34136078 Free PMC article.
Modulating protein-protein interaction networks in protein homeostasis.
Zhong M, Lee GM, Sijbesma E, Ottmann C, Arkin MR. Zhong M, et al. Among authors: sijbesma e. Curr Opin Chem Biol. 2019 Jun;50:55-65. doi: 10.1016/j.cbpa.2019.02.012. Epub 2019 Mar 23. Curr Opin Chem Biol. 2019. PMID: 30913483 Free PMC article. Review.
Stabilization of protein-protein interactions in drug discovery.
Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C. Andrei SA, et al. Among authors: sijbesma e. Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Expert Opin Drug Discov. 2017. PMID: 28695752 Free article. Review.
Modulators of 14-3-3 Protein-Protein Interactions.
Stevers LM, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson AJ, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston RG, Brunsveld L, Ottmann C. Stevers LM, et al. Among authors: sijbesma e. J Med Chem. 2018 May 10;61(9):3755-3778. doi: 10.1021/acs.jmedchem.7b00574. Epub 2017 Oct 19. J Med Chem. 2018. PMID: 28968506 Free PMC article. Review.
17 results