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Localised Cdr1as activity is required for fear extinction memory.
Zajaczkowski EL, Zhao Q, Liau WS, Gong H, Madugalle SU, Periyakaruppiah A, Leighton LJ, Musgrove M, Ren H, Davies J, Marshall PR, Bredy TW. Zajaczkowski EL, et al. Among authors: leighton lj. Neurobiol Learn Mem. 2023 Sep;203:107777. doi: 10.1016/j.nlm.2023.107777. Epub 2023 May 29. Neurobiol Learn Mem. 2023. PMID: 37257557
The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory.
Li X, Marshall PR, Leighton LJ, Zajaczkowski EL, Wang Z, Madugalle SU, Yin J, Bredy TW, Wei W. Li X, et al. Among authors: leighton lj. J Neurosci. 2019 Feb 6;39(6):970-983. doi: 10.1523/JNEUROSCI.2024-18.2018. Epub 2018 Dec 13. J Neurosci. 2019. PMID: 30545945 Free PMC article.
The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Li X, Zhao Q, Wei W, Lin Q, Magnan C, Emami MR, Wearick-Silva LE, Viola TW, Marshall PR, Yin J, Madugalle SU, Wang Z, Nainar S, Vågbø CB, Leighton LJ, Zajaczkowski EL, Ke K, Grassi-Oliveira R, Bjørås M, Baldi PF, Spitale RC, Bredy TW. Li X, et al. Among authors: leighton lj. Nat Neurosci. 2019 Apr;22(4):534-544. doi: 10.1038/s41593-019-0339-x. Epub 2019 Feb 18. Nat Neurosci. 2019. PMID: 30778148 Free PMC article.
Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction.
Marshall PR, Zhao Q, Li X, Wei W, Periyakaruppiah A, Zajaczkowski EL, Leighton LJ, Madugalle SU, Basic D, Wang Z, Yin J, Liau WS, Gupte A, Walkley CR, Bredy TW. Marshall PR, et al. Among authors: leighton lj. Nat Neurosci. 2020 Jun;23(6):718-729. doi: 10.1038/s41593-020-0627-5. Epub 2020 May 4. Nat Neurosci. 2020. PMID: 32367065 Free PMC article.
17 results