Scialis RJ - Search Results

1

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.

Zhuo X, Howell BA, Shen H, Woodhead JL, Mosure K, Zhang Y, Scialis RJ, Iyer R, Sun Y, Boy KM, Lentz KA, Denton RR, Soars MG, Johnson BM, Humphreys WG. Zhuo X, et al. Among authors: scialis rj. Toxicol Sci. 2023 Jul 28;194(2):235-245. doi: 10.1093/toxsci/kfad057. Toxicol Sci. 2023. PMID: 37261863

2

Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes.

Yoshikado T, Lee W, Toshimoto K, Morita K, Kiriake A, Chu X, Lee N, Kimoto E, Varma MVS, Kikuchi R, Scialis RJ, Shen H, Ishiguro N, Lotz R, Li AP, Maeda K, Kusuhara H, Sugiyama Y. Yoshikado T, et al. Among authors: scialis rj. J Pharm Sci. 2021 Jan;110(1):376-387. doi: 10.1016/j.xphs.2020.10.041. Epub 2020 Oct 27. J Pharm Sci. 2021. PMID: 33122051

3

Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs.

Lee W, Koyama S, Morita K, Kiriake A, Kikuchi R, Chu X, Lee N, Scialis RJ, Shen H, Kimoto E, Tremaine L, Ishiguro N, Lotz R, Maeda K, Kusuhara H, Sugiyama Y. Lee W, et al. Among authors: scialis rj. AAPS J. 2020 Oct 15;22(6):133. doi: 10.1208/s12248-020-00512-6. AAPS J. 2020. PMID: 33063163 Free PMC article.

4

The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites.

Scialis RJ, Ghanem CI, Manautou JE. Scialis RJ, et al. Curr Res Toxicol. 2020 Apr 30;1:34-41. doi: 10.1016/j.crtox.2020.04.002. eCollection 2020 Jun 10. Curr Res Toxicol. 2020. PMID: 34345835 Free PMC article.

5

Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.

Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE. Scialis RJ, et al. Drug Metab Dispos. 2019 Oct;47(10):1080-1092. doi: 10.1124/dmd.119.086603. Epub 2019 Aug 9. Drug Metab Dispos. 2019. PMID: 31399506 Free PMC article.

6

Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1.

Kimoto E, Vourvahis M, Scialis RJ, Eng H, Rodrigues AD, Varma MVS. Kimoto E, et al. Among authors: scialis rj. Drug Metab Dispos. 2019 May;47(5):493-503. doi: 10.1124/dmd.118.085241. Epub 2019 Mar 12. Drug Metab Dispos. 2019. PMID: 30862625

7

Xenobiotic Transporters in the Kidney: Function and Role in Toxicity.

Shen H, Scialis RJ, Lehman-McKeeman L. Shen H, et al. Among authors: scialis rj. Semin Nephrol. 2019 Mar;39(2):159-175. doi: 10.1016/j.semnephrol.2018.12.010. Semin Nephrol. 2019. PMID: 30827339 Review.

8

Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites.

Li R, Bi YA, Vildhede A, Scialis RJ, Mathialagan S, Yang X, Marroquin LD, Lin J, Varma MVS. Li R, et al. Among authors: scialis rj. Drug Metab Dispos. 2017 Jul;45(7):737-747. doi: 10.1124/dmd.116.074815. Epub 2017 Apr 24. Drug Metab Dispos. 2017. PMID: 28438781

9

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS. Bi YA, et al. Among authors: scialis rj. AAPS J. 2017 May;19(3):882. doi: 10.1208/s12248-017-0061-0. AAPS J. 2017. PMID: 28233243 No abstract available.

10

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS. Bi YA, et al. Among authors: scialis rj. AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. AAPS J. 2017. PMID: 28188574

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