Shen H - Search Results

1

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.

Zhuo X, Howell BA, Shen H, Woodhead JL, Mosure K, Zhang Y, Scialis RJ, Iyer R, Sun Y, Boy KM, Lentz KA, Denton RR, Soars MG, Johnson BM, Humphreys WG. Zhuo X, et al. Among authors: shen h. Toxicol Sci. 2023 Jul 28;194(2):235-245. doi: 10.1093/toxsci/kfad057. Toxicol Sci. 2023. PMID: 37261863

2

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.

Gan J, Chen W, Shen H, Gao L, Hong Y, Tian Y, Li W, Zhang Y, Tang Y, Zhang H, Humphreys WG, Rodrigues AD. Gan J, et al. Among authors: shen h. Br J Clin Pharmacol. 2010 Dec;70(6):870-80. doi: 10.1111/j.1365-2125.2010.03772.x. Br J Clin Pharmacol. 2010. PMID: 21175442 Free PMC article.

3

Assessment of vandetanib as an inhibitor of various human renal transporters: inhibition of multidrug and toxin extrusion as a possible mechanism leading to decreased cisplatin and creatinine clearance.

Shen H, Yang Z, Zhao W, Zhang Y, Rodrigues AD. Shen H, et al. Drug Metab Dispos. 2013 Dec;41(12):2095-103. doi: 10.1124/dmd.113.053215. Epub 2013 Sep 11. Drug Metab Dispos. 2013. PMID: 24026623

4

Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.

Shen H, Su H, Liu T, Yao M, Mintier G, Li L, Fancher RM, Iyer R, Marathe P, Lai Y, Rodrigues AD. Shen H, et al. J Pharmacol Exp Ther. 2015 May;353(2):380-91. doi: 10.1124/jpet.114.221804. Epub 2015 Mar 4. J Pharmacol Exp Ther. 2015. PMID: 25740896

5

Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.

Morse BL, Cai H, MacGuire JG, Fox M, Zhang L, Zhang Y, Gu X, Shen H, Dierks EA, Su H, Luk CE, Marathe P, Shu YZ, Humphreys WG, Lai Y. Morse BL, et al. Among authors: shen h. Drug Metab Dispos. 2015 Nov;43(11):1788-94. doi: 10.1124/dmd.115.065946. Epub 2015 Sep 4. Drug Metab Dispos. 2015. PMID: 26341276

6

Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.

Shen H, Dai J, Liu T, Cheng Y, Chen W, Freeden C, Zhang Y, Humphreys WG, Marathe P, Lai Y. Shen H, et al. J Pharmacol Exp Ther. 2016 May;357(2):382-93. doi: 10.1124/jpet.116.232066. Epub 2016 Feb 23. J Pharmacol Exp Ther. 2016. PMID: 26907622

7

Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.

Qiu X, Zhang Y, Liu T, Shen H, Xiao Y, Bourner MJ, Pratt JR, Thompson DC, Marathe P, Humphreys WG, Lai Y. Qiu X, et al. Among authors: shen h. Mol Pharm. 2016 Apr 4;13(4):1206-16. doi: 10.1021/acs.molpharmaceut.5b00659. Epub 2016 Mar 8. Mol Pharm. 2016. PMID: 26910619

8

Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.

Cheng Y, Freeden C, Zhang Y, Abraham P, Shen H, Wescott D, Humphreys WG, Gan J, Lai Y. Cheng Y, et al. Among authors: shen h. Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. Biopharm Drug Dispos. 2016. PMID: 27059119

9

Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.

Lai Y, Mandlekar S, Shen H, Holenarsipur VK, Langish R, Rajanna P, Murugesan S, Gaud N, Selvam S, Date O, Cheng Y, Shipkova P, Dai J, Humphreys WG, Marathe P. Lai Y, et al. Among authors: shen h. J Pharmacol Exp Ther. 2016 Sep;358(3):397-404. doi: 10.1124/jpet.116.234914. Epub 2016 Jun 17. J Pharmacol Exp Ther. 2016. PMID: 27317801 Clinical Trial.

10

Tissue distribution and tumor uptake of folate receptor-targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration.

Shen H, Wang L, Chen W, Menard K, Hong Y, Tian Y, Bonacorsi SJ, Humphreys WG, Lee FY, Gan J. Shen H, et al. Acta Pharm Sin B. 2016 Sep;6(5):460-467. doi: 10.1016/j.apsb.2016.07.009. Epub 2016 Aug 11. Acta Pharm Sin B. 2016. PMID: 27709015 Free PMC article.

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