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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.
Arwood ML, Liu Y, Harkins SK, Weinstock DM, Yang L, Stevenson KE, Plana OD, Dong J, Cirka H, Jones KL, Virtanen AT, Gupta DG, Ceas A, Lawney B, Yoda A, Leahy C, Hao M, He Z, Choi HG, Wang Y, Silvennoinen O, Hubbard SR, Zhang T, Gray NS, Li LS. Arwood ML, et al. Among authors: hubbard sr. Cell Chem Biol. 2023 Jun 15;30(6):618-631.e12. doi: 10.1016/j.chembiol.2023.05.007. Epub 2023 Jun 7. Cell Chem Biol. 2023. PMID: 37290440 Free PMC article.
Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Virtanen AT, Haikarainen T, Sampathkumar P, Palmroth M, Liukkonen S, Liu J, Nekhotiaeva N, Hubbard SR, Silvennoinen O. Virtanen AT, et al. Among authors: hubbard sr. Pharmaceuticals (Basel). 2023 Jan 4;16(1):75. doi: 10.3390/ph16010075. Pharmaceuticals (Basel). 2023. PMID: 36678572 Free PMC article.
Structural basis of Janus kinase trans-activation.
Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC. Caveney NA, et al. Among authors: hubbard sr. Cell Rep. 2023 Mar 28;42(3):112201. doi: 10.1016/j.celrep.2023.112201. Epub 2023 Mar 2. Cell Rep. 2023. PMID: 36867534 Free PMC article.
Unlocking the secrets to Janus kinase activation.
Levine RL, Hubbard SR. Levine RL, et al. Among authors: hubbard sr. Science. 2022 Apr 8;376(6589):139-140. doi: 10.1126/science.abo7788. Epub 2022 Apr 7. Science. 2022. PMID: 35389811
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD, Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, Vattulainen I, Hitchcock IS, Piehler J. Wilmes S, et al. Among authors: hubbard sr. Science. 2020 Feb 7;367(6478):643-652. doi: 10.1126/science.aaw3242. Science. 2020. PMID: 32029621 Free PMC article.
KRAS4A directly regulates hexokinase 1.
Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Court H, Shi J, Mendoza SL, Morten MJ, Rothenberg E, Gottlieb E, Wadghiri YZ, Possemato R, Hubbard SR, Balmain A, Kimmelman AC, Philips MR. Amendola CR, et al. Among authors: hubbard sr. Nature. 2019 Dec;576(7787):482-486. doi: 10.1038/s41586-019-1832-9. Epub 2019 Dec 11. Nature. 2019. PMID: 31827279 Free PMC article.
98 results