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Safety, pharmacokinetics, and antiretroviral activity of islatravir (ISL, MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor, following single-dose administration to treatment-naive adults infected with HIV-1: an open-label, phase 1b, consecutive-panel trial.
Schürmann D, Rudd DJ, Zhang S, De Lepeleire I, Robberechts M, Friedman E, Keicher C, Hüser A, Hofmann J, Grobler JA, Stoch SA, Iwamoto M, Matthews RP. Schürmann D, et al. Among authors: matthews rp. Lancet HIV. 2020 Mar;7(3):e164-e172. doi: 10.1016/S2352-3018(19)30372-8. Epub 2020 Jan 3. Lancet HIV. 2020. PMID: 31911147 Clinical Trial.
Lack of a Clinically Meaningful Drug Interaction Between the HIV-1 Antiretroviral Agents Islatravir, Dolutegravir, and Tenofovir Disoproxil Fumarate.
Rudd DJ, Zhang S, Fillgrove KL, Fox-Bosetti S, Matthews RP, Friedman E, Armas D, Stoch SA, Iwamoto M. Rudd DJ, et al. Among authors: matthews rp. Clin Pharmacol Drug Dev. 2021 Dec;10(12):1432-1441. doi: 10.1002/cpdd.1026. Epub 2021 Oct 22. Clin Pharmacol Drug Dev. 2021. PMID: 34676683 Free PMC article. Clinical Trial.
A phase 1, open-label study to evaluate the drug interaction between islatravir (MK-8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females.
Ankrom W, Jackson Rudd D, Zhang S, Fillgrove KL, Gravesande KN, Matthews RP, Brimhall D, Stoch SA, Iwamoto MN. Ankrom W, et al. Among authors: matthews rp. J Int AIDS Soc. 2021 Dec;24(12):e25858. doi: 10.1002/jia2.25858. J Int AIDS Soc. 2021. PMID: 34935295 Free PMC article. Clinical Trial.
Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma.
Sun L, Xu Y, Dube N, Anderson M, Breidinger S, Vaddady P, Thornton B, Morrow L, Matthews RP, Stoch SA, Woolf EJ. Sun L, et al. Among authors: matthews rp. J Pharm Biomed Anal. 2022 Apr 1;212:114639. doi: 10.1016/j.jpba.2022.114639. Epub 2022 Feb 2. J Pharm Biomed Anal. 2022. PMID: 35176654
Safety and Pharmacokinetics of Islatravir in Individuals with Severe Renal Insufficiency.
Matthews RP, Cao Y, Patel M, Weissler VL, Bhattacharyya A, De Lepeleire I, Last S, Rondon JC, Vargo R, Stoch SA, Iwamoto M. Matthews RP, et al. Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0093122. doi: 10.1128/aac.00931-22. Epub 2022 Nov 8. Antimicrob Agents Chemother. 2022. PMID: 36346229 Free PMC article. Clinical Trial.
80 results