Kuai L - Search Results

1

DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor.

Silvestri AP, Zhang Q, Ping Y, Muir EW, Zhao J, Chakka SK, Wang G, Bray WM, Chen W, Fribourgh JL, Tripathi S, He Y, Rubin SM, Satz AL, Pye CR, Kuai L, Su W, Schwochert JA. Silvestri AP, et al. Among authors: kuai l. ACS Med Chem Lett. 2023 May 5;14(6):820-826. doi: 10.1021/acsmedchemlett.3c00117. eCollection 2023 Jun 8. ACS Med Chem Lett. 2023. PMID: 37312849 Free PMC article.

2

DNA Compatible Intermolecular Wittig Olefination for the Construction of α, β-Unsaturated Carbonyl Compounds.

An YL, Li K, Shen Y, Hong Z, Chen L, Hu Y, Zhou L, Wang D, Shi X, Liu S, Su W, Cui W, Kuai L, Yang H, Peng X. An YL, et al. Among authors: kuai l. Org Lett. 2020 May 15;22(10):3931-3935. doi: 10.1021/acs.orglett.0c01215. Epub 2020 May 4. Org Lett. 2020. PMID: 32364391

3

Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis.

Qu Y, Liu S, Wen H, Xu Y, An Y, Li K, Ni M, Shen Y, Shi X, Su W, Cui W, Kuai L, Satz AL, Yang H, Lu X, Peng X. Qu Y, et al. Among authors: kuai l. Biochem Biophys Res Commun. 2020 Dec 3;533(2):209-214. doi: 10.1016/j.bbrc.2020.04.027. Epub 2020 May 4. Biochem Biophys Res Commun. 2020. PMID: 32376009

4

Copper-Mediated DNA-Compatible One-Pot Click Reactions of Alkynes with Aryl Borates and TMS-N₃.

Qu Y, Wen H, Ge R, Xu Y, Gao H, Shi X, Wang J, Cui W, Su W, Yang H, Kuai L, Satz AL, Peng X. Qu Y, et al. Among authors: kuai l. Org Lett. 2020 Jun 5;22(11):4146-4150. doi: 10.1021/acs.orglett.0c01219. Epub 2020 May 8. Org Lett. 2020. PMID: 32383596

5

Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering.

Li K, Liu X, Liu S, An Y, Shen Y, Sun Q, Shi X, Su W, Cui W, Duan Z, Kuai L, Yang H, Satz AL, Chen K, Jiang H, Zheng M, Peng X, Lu X. Li K, et al. Among authors: kuai l. iScience. 2020 Jun 26;23(6):101142. doi: 10.1016/j.isci.2020.101142. Epub 2020 May 7. iScience. 2020. PMID: 32446221 Free PMC article.

6

DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines.

Li K, Qu Y, An Y, Breinlinger E, Webster MP, Wen H, Ding D, Zhao M, Shi X, Wang J, Su W, Cui W, Satz AL, Yang H, Kuai L, Little A, Peng X. Li K, et al. Among authors: kuai l. Bioconjug Chem. 2020 Sep 16;31(9):2092-2097. doi: 10.1021/acs.bioconjchem.0c00392. Epub 2020 Aug 20. Bioconjug Chem. 2020. PMID: 32804494

7

Synthesis of 1,2-Amino Alcohols by Photoredox-Mediated Decarboxylative Coupling of α-Amino Acids and DNA-Conjugated Carbonyls.

Wen H, Ge R, Qu Y, Sun J, Shi X, Cui W, Yan H, Zhang Q, An Y, Su W, Yang H, Kuai L, Satz AL, Peng X. Wen H, et al. Among authors: kuai l. Org Lett. 2020 Dec 18;22(24):9484-9489. doi: 10.1021/acs.orglett.0c03461. Epub 2020 Nov 10. Org Lett. 2020. PMID: 33170713

8

Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets.

Satz AL, Kuai L, Peng X. Satz AL, et al. Among authors: kuai l. Bioorg Med Chem Lett. 2021 May 1;39:127851. doi: 10.1016/j.bmcl.2021.127851. Epub 2021 Feb 23. Bioorg Med Chem Lett. 2021. PMID: 33631371 Free article. Review.

9

Triaging of DNA-Encoded Library Selection Results by High-Throughput Resynthesis of DNA-Conjugate and Affinity Selection Mass Spectrometry.

Su W, Ge R, Ding D, Chen W, Wang W, Yan H, Wang W, Yuan Y, Liu H, Zhang M, Zhang J, Shu Q, Satz AL, Kuai L. Su W, et al. Among authors: kuai l. Bioconjug Chem. 2021 May 19;32(5):1001-1007. doi: 10.1021/acs.bioconjchem.1c00170. Epub 2021 Apr 29. Bioconjug Chem. 2021. PMID: 33914520 Free article.

10

Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection.

Ge R, Shen Z, Yin J, Chen W, Zhang Q, An Y, Tang D, Satz AL, Su W, Kuai L. Ge R, et al. Among authors: kuai l. SLAS Discov. 2022 Mar;27(2):79-85. doi: 10.1016/j.slasd.2022.01.001. Epub 2022 Jan 19. SLAS Discov. 2022. PMID: 35063690 Free PMC article.

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