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eTRANSAFE: data science to empower translational safety assessment.
Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Asakura S, Amberg A, Bécourt-Lhote N, Blomberg N, Bosc N, Briggs K, Bringezu F, Brulle-Wohlhueter C, Brunak S, Bueters R, Callegaro G, Capella-Gutierrez S, Centeno E, Corvi J, Cronin MTD, Drew P, Duchateau-Nguyen G, Ecker GF, Escher S, Felix E, Ferreiro M, Frericks M, Furlong LI, Geiger R, George C, Grandits M, Ivanov-Draganov D, Kilgour-Christie J, Kiziloren T, Kors JA, Koyama N, Kreuchwig A, Leach AR, Mayer MA, Monecke P, Muster W, Nakazawa CM, Nicholson G, Parry R, Pastor M, Piñero J, Oberhauser N, Ramírez-Anguita JM, Rodrigo A, Smajic A, Schaefer M, Schieferdecker S, Soininen I, Terricabras E, Trairatphisan P, Turner SC, Valencia A, van de Water B, van der Lei JL, van Mulligen EM, Vock E, Wilkinson D. Sanz F, et al. Among authors: trairatphisan p. Nat Rev Drug Discov. 2023 Aug;22(8):605-606. doi: 10.1038/d41573-023-00099-5. Nat Rev Drug Discov. 2023. PMID: 37316648 No abstract available.
Identifying multiscale translational safety biomarkers using a network-based systems approach.
Callegaro G, Schimming JP, Piñero González J, Kunnen SJ, Wijaya L, Trairatphisan P, van den Berk L, Beetsma K, Furlong LI, Sutherland JJ, Mollon J, Stevens JL, van de Water B. Callegaro G, et al. Among authors: trairatphisan p. iScience. 2023 Jan 31;26(3):106094. doi: 10.1016/j.isci.2023.106094. eCollection 2023 Mar 17. iScience. 2023. PMID: 36895646 Free PMC article.
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment.
Callegaro G, Kunnen SJ, Trairatphisan P, Grosdidier S, Niemeijer M, den Hollander W, Guney E, Piñero Gonzalez J, Furlong L, Webster YW, Saez-Rodriguez J, Sutherland JJ, Mollon J, Stevens JL, van de Water B. Callegaro G, et al. Among authors: trairatphisan p. Arch Toxicol. 2021 Dec;95(12):3745-3775. doi: 10.1007/s00204-021-03141-w. Epub 2021 Oct 9. Arch Toxicol. 2021. PMID: 34626214 Free PMC article.
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.
Wijaya LS, Trairatphisan P, Gabor A, Niemeijer M, Keet J, Alcalà Morera A, Snijders KE, Wink S, Yang H, Schildknecht S, Stevens JL, Bouwman P, Kamp H, Hengstler J, Beltman J, Leist M, Le Dévédec S, Saez-Rodriguez J, van de Water B. Wijaya LS, et al. Among authors: trairatphisan p. Biochem Pharmacol. 2021 Aug;190:114591. doi: 10.1016/j.bcp.2021.114591. Epub 2021 May 4. Biochem Pharmacol. 2021. PMID: 33957093 Free article.
Dysregulated mesenchymal PDGFR-β drives kidney fibrosis.
Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. Buhl EM, et al. Among authors: trairatphisan p. EMBO Mol Med. 2020 Mar 6;12(3):e11021. doi: 10.15252/emmm.201911021. Epub 2020 Jan 14. EMBO Mol Med. 2020. PMID: 31943786 Free PMC article.
16 results