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A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.
Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL. Cline EN, et al. Among authors: dinunno n. J Neurochem. 2019 Mar;148(6):822-836. doi: 10.1111/jnc.14647. Epub 2019 Jan 29. J Neurochem. 2019. PMID: 30565253 Free PMC article.
Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL. Pitt J, et al. Among authors: dinunno n. Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9. Mol Biol Cell. 2017. PMID: 28963439 Free PMC article.
A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.
Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL. Sebollela A, et al. Among authors: dinunno n. J Neurochem. 2017 Sep;142(6):934-947. doi: 10.1111/jnc.14118. Epub 2017 Aug 2. J Neurochem. 2017. PMID: 28670737 Free PMC article.
14 results