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Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections.
Promsote W, Xu L, Hataye J, Fabozzi G, March K, Almasri CG, DeMouth ME, Lovelace SE, Talana CA, Doria-Rose NA, McKee K, Hait SH, Casazza JP, Ambrozak D, Beninga J, Rao E, Furtmann N, Birkenfeld J, McCarthy E, Todd JP, Petrovas C, Connors M, Hebert AT, Beck J, Shen J, Zhang B, Levit M, Wei RR, Yang ZY, Pegu A, Mascola JR, Nabel GJ, Koup RA. Promsote W, et al. Among authors: petrovas c. Nat Commun. 2023 Jun 22;14(1):3719. doi: 10.1038/s41467-023-39265-z. Nat Commun. 2023. PMID: 37349337 Free PMC article.
No evidence of epitope spreading after immunization with the major Sm epitope P-P-G-M-R-P-P anchored to sequential oligopeptide carriers (SOCs).
Vlachoyiannopoulos PG, Petrovas C, Tzioufas AG, Alexopoulos C, Tsikaris V, Guialis A, Nakopoulou L, Sakarellos-Daitsiotis M, Sakarellos C, Davaris P, Moutsopoulos HM. Vlachoyiannopoulos PG, et al. Among authors: petrovas c. J Autoimmun. 2000 Feb;14(1):53-61. doi: 10.1006/jaut.1999.0344. J Autoimmun. 2000. PMID: 10648116
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.
Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, Precopio ML, Schacker T, Roederer M, Douek DC, Koup RA. Petrovas C, et al. J Exp Med. 2006 Oct 2;203(10):2281-92. doi: 10.1084/jem.20061496. Epub 2006 Sep 5. J Exp Med. 2006. PMID: 16954372 Free PMC article.
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA. Petrovas C, et al. Blood. 2007 Aug 1;110(3):928-36. doi: 10.1182/blood-2007-01-069112. Epub 2007 Apr 17. Blood. 2007. PMID: 17440051 Free PMC article.
Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
Cecchinato V, Tryniszewska E, Ma ZM, Vaccari M, Boasso A, Tsai WP, Petrovas C, Fuchs D, Heraud JM, Venzon D, Shearer GM, Koup RA, Lowy I, Miller CJ, Franchini G. Cecchinato V, et al. Among authors: petrovas c. J Immunol. 2008 Apr 15;180(8):5439-47. doi: 10.4049/jimmunol.180.8.5439. J Immunol. 2008. PMID: 18390726 Free PMC article.
102 results