O'Donoghue AJ - Search Results

1

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.

Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi TC, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, Vigneron S, Young NJ, Kondratov IS, Alisoltani A, Simons LM, Lorenzo-Redondo R, Ozer EA, Hultquist JF, O'Donoghue AJ, Moroz YS, Taunton J, Renslo AR, Irwin JJ, García-Sastre A, Shoichet BK, Craik CS. Fink EA, et al. Protein Sci. 2023 Aug;32(8):e4712. doi: 10.1002/pro.4712. Protein Sci. 2023. PMID: 37354015 Free PMC article.

2

A parasite cysteine protease is key to host protein degradation and iron acquisition.

O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. O'Brien TC, et al. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18701454 Free PMC article.

3

Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii.

Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG. Mahon CS, et al. Microbiology (Reading). 2009 Nov;155(Pt 11):3673-3682. doi: 10.1099/mic.0.030940-0. Epub 2009 Jun 25. Microbiology (Reading). 2009. PMID: 19556294 Free PMC article.

4

Global identification of peptidase specificity by multiplex substrate profiling.

O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. O'Donoghue AJ, et al. Nat Methods. 2012 Nov;9(11):1095-100. doi: 10.1038/nmeth.2182. Epub 2012 Sep 30. Nat Methods. 2012. PMID: 23023596 Free PMC article.

5

Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.

Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. Small JL, et al. J Biol Chem. 2013 May 3;288(18):12489-99. doi: 10.1074/jbc.M113.456541. Epub 2013 Mar 15. J Biol Chem. 2013. PMID: 23504313 Free PMC article.

6

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.

O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW. O'Donoghue AJ, et al. PLoS One. 2013 Sep 20;8(9):e75141. doi: 10.1371/journal.pone.0075141. eCollection 2013. PLoS One. 2013. PMID: 24073241 Free PMC article.

7

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.

Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D. Sharma V, et al. Biochem J. 2015 Jan 1;465(1):163-73. doi: 10.1042/BJ20140809. Biochem J. 2015. PMID: 25279554

8

Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome.

O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. O'Donoghue AJ, et al. Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7478-83. doi: 10.1073/pnas.1507082112. Epub 2015 May 5. Proc Natl Acad Sci U S A. 2015. PMID: 25944934 Free PMC article.

9

Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.

Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. Dvořák J, et al. Biochimie. 2016 Mar;122:99-109. doi: 10.1016/j.biochi.2015.09.025. Epub 2015 Sep 26. Biochimie. 2016. PMID: 26409899 Free PMC article.

10

Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion.

Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F. Bibo-Verdugo B, et al. Mar Biotechnol (NY). 2016 Apr;18(2):201-14. doi: 10.1007/s10126-015-9681-5. Epub 2015 Nov 27. Mar Biotechnol (NY). 2016. PMID: 26613762 Free article.

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