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Page 1
WNK1 enforces macrophage lineage fidelity.
Trzeciak AJ, Rojas WS, Liu ZL, Krebs AS, Wang Z, Saavedra PHV, Miranda IC, Lipshutz A, Xie J, Huang CL, Overholtzer M, Glickman MS, Parkhurst CN, Vierbuchen T, Lucas CD, Perry JSA. Trzeciak AJ, et al. Among authors: saavedra phv. bioRxiv [Preprint]. 2023 Apr 28:2023.04.26.538482. doi: 10.1101/2023.04.26.538482. bioRxiv. 2023. PMID: 37383948 Free PMC article. Preprint.
Early life high fructose exposure disrupts microglia function and impedes neurodevelopment.
Wang Z, Lipshutz A, Liu ZL, Trzeciak AJ, Miranda IC, Martínez de la Torre C, Schild T, Lazarov T, Rojas WS, Saavedra PHV, Romero-Pichardo JE, Baako A, Geissmann F, Faraco G, Gan L, Etchegaray JI, Lucas CD, Parkhurst CN, Zeng MY, Keshari KR, Perry JSA. Wang Z, et al. Among authors: saavedra phv. bioRxiv [Preprint]. 2023 Aug 15:2023.08.14.553242. doi: 10.1101/2023.08.14.553242. bioRxiv. 2023. PMID: 37645894 Free PMC article. Preprint.
Kidney macrophages tap the stream.
Saavedra PHV, Perry JSA. Saavedra PHV, et al. Immunity. 2024 Jan 9;57(1):3-5. doi: 10.1016/j.immuni.2023.12.008. Immunity. 2024. PMID: 38198853
Broad-spectrum antibiotics disrupt homeostatic efferocytosis.
Saavedra PHV, Trzeciak AJ, Lipshutz A, Daman AW, O'Neal AJ, Liu ZL, Wang Z, Romero-Pichardo JE, Rojas WS, Zago G, van den Brink MRM, Josefowicz SZ, Lucas CD, Anderson CJ, Rudensky AY, Perry JSA. Saavedra PHV, et al. Nat Metab. 2024 Sep;6(9):1682-1694. doi: 10.1038/s42255-024-01107-7. Epub 2024 Aug 9. Nat Metab. 2024. PMID: 39122784 Free PMC article.
Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice.
Dufies O, Doye A, Courjon J, Torre C, Michel G, Loubatier C, Jacquel A, Chaintreuil P, Majoor A, Guinamard RR, Gallerand A, Saavedra PHV, Verhoeyen E, Rey A, Marchetti S, Ruimy R, Czerucka D, Lamkanfi M, Py BF, Munro P, Visvikis O, Boyer L. Dufies O, et al. Among authors: saavedra phv. Nat Microbiol. 2021 Mar;6(3):401-412. doi: 10.1038/s41564-020-00832-5. Epub 2021 Jan 11. Nat Microbiol. 2021. PMID: 33432150 Free PMC article.
Cryptococcus neoformans Secretes Small Molecules That Inhibit IL-1β Inflammasome-Dependent Secretion.
Bürgel PH, Marina CL, Saavedra PHV, Albuquerque P, de Oliveira SAM, Veloso Janior PHH, de Castro RA, Heyman HM, Coelho C, Cordero RJB, Casadevall A, Nosanchuk JD, Nakayasu ES, May RC, Tavares AH, Bocca AL. Bürgel PH, et al. Among authors: saavedra phv. Mediators Inflamm. 2020 Dec 3;2020:3412763. doi: 10.1155/2020/3412763. eCollection 2020. Mediators Inflamm. 2020. PMID: 33380899 Free PMC article.
IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D.
Kiss M, Vande Walle L, Saavedra PHV, Lebegge E, Van Damme H, Murgaski A, Qian J, Ehling M, Pretto S, Bolli E, Keirsse J, Bardet PMR, Arnouk SM, Elkrim Y, Schmoetten M, Brughmans J, Debraekeleer A, Fossoul A, Boon L, Raes G, van Loo G, Lambrechts D, Mazzone M, Beschin A, Wullaert A, Lamkanfi M, Van Ginderachter JA, Laoui D. Kiss M, et al. Among authors: saavedra phv. Cancer Immunol Res. 2021 Mar;9(3):309-323. doi: 10.1158/2326-6066.CIR-20-0431. Epub 2020 Dec 23. Cancer Immunol Res. 2021. PMID: 33361087
Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
Walle LV, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubr V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M. Walle LV, et al. Among authors: saavedra phv. PLoS Biol. 2019 Oct 16;17(10):e3000529. doi: 10.1371/journal.pbio.3000529. eCollection 2019 Oct. PLoS Biol. 2019. PMID: 31618263 Free PMC article.
18 results