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Page 1
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
Kettle JG, Bagal SK, Barratt D, Bodnarchuk MS, Boyd S, Braybrooke E, Breed J, Cassar DJ, Cosulich S, Davies M, Davies NL, Deng C, Eatherton A, Evans L, Feron LJ, Fillery S, Gleave ES, Goldberg FW, Cortés González MA, Guerot C, Haider A, Harlfinger S, Howells R, Jackson A, Johnström P, Kemmitt PD, Koers A, Kondrashov M, Lamont GM, Lamont S, Lewis HJ, Liu L, Mylrea M, Nash S, Niedbala MJ, Peter A, Phillips C, Pike K, Raubo P, Robb GR, Ross S, Sanders MG, Schou M, Simpson I, Steward O. Kettle JG, et al. Among authors: cortes gonzalez ma. J Med Chem. 2023 Jul 13;66(13):9147-9160. doi: 10.1021/acs.jmedchem.3c00746. Epub 2023 Jul 3. J Med Chem. 2023. PMID: 37395055
Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides.
Gómez AB, Cortés González MA, Lübcke M, Johansson MJ, Halldin C, Szabó KJ, Schou M. Gómez AB, et al. Among authors: cortes gonzalez ma. Chem Commun (Camb). 2016 Nov 29;52(97):13963-13966. doi: 10.1039/c6cc08535k. Chem Commun (Camb). 2016. PMID: 27844069
Simplified and accessible [18 F]F-AraG synthesis procedure for preclinical PET.
Högnäsbacka AA, Cortés González MA, Halldin C, Schou M. Högnäsbacka AA, et al. Among authors: cortes gonzalez ma. J Labelled Comp Radiopharm. 2022 Aug;65(10-11):288-291. doi: 10.1002/jlcr.3997. Epub 2022 Aug 23. J Labelled Comp Radiopharm. 2022. PMID: 35980801 Free PMC article.
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.
Staniszewska AD, Pilger D, Gill SJ, Jamal K, Bohin N, Guzzetti S, Gordon J, Hamm G, Mundin G, Illuzzi G, Pike A, McWilliams L, Maglennon G, Rose J, Hawthorne G, Cortes Gonzalez M, Halldin C, Johnström P, Schou M, Critchlow SE, Fawell S, Johannes JW, Leo E, Davies BR, Cosulich S, Sarkaria JN, O'Connor MJ, Hamerlik P. Staniszewska AD, et al. Clin Cancer Res. 2024 Apr 1;30(7):1338-1351. doi: 10.1158/1078-0432.CCR-23-2094. Clin Cancer Res. 2024. PMID: 37967136