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MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
Pérez-Cabello JA, Silvera-Carrasco L, Franco JM, Capilla-González V, Armaos A, Gómez-Lima M, García-García R, Yap XW, Leal-Lasarte M, Lall D, Baloh RH, Martínez S, Miyata Y, Tartaglia GG, Sawarkar R, García-Domínguez M, Pozo D, Roodveldt C. Pérez-Cabello JA, et al. Among authors: roodveldt c. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2302143120. doi: 10.1073/pnas.2302143120. Epub 2023 Jul 3. Proc Natl Acad Sci U S A. 2023. PMID: 37399380 Free PMC article.
Enzyme promiscuity: evolutionary and mechanistic aspects.
Khersonsky O, Roodveldt C, Tawfik DS. Khersonsky O, et al. Among authors: roodveldt c. Curr Opin Chem Biol. 2006 Oct;10(5):498-508. doi: 10.1016/j.cbpa.2006.08.011. Epub 2006 Aug 30. Curr Opin Chem Biol. 2006. PMID: 16939713 Review.
The 'evolvability' of promiscuous protein functions.
Aharoni A, Gaidukov L, Khersonsky O, McQ Gould S, Roodveldt C, Tawfik DS. Aharoni A, et al. Among authors: roodveldt c. Nat Genet. 2005 Jan;37(1):73-6. doi: 10.1038/ng1482. Epub 2004 Nov 28. Nat Genet. 2005. PMID: 15568024
30 results