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A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.
Losa M, Barozzi I, Osterwalder M, Hermosilla-Aguayo V, Morabito A, Chacón BH, Zarrineh P, Girdziusaite A, Benazet JD, Zhu J, Mackem S, Capellini TD, Dickel D, Bobola N, Zuniga A, Visel A, Zeller R, Selleri L. Losa M, et al. Among authors: zhu j. Nat Commun. 2023 Jul 6;14(1):3993. doi: 10.1038/s41467-023-39443-z. Nat Commun. 2023. PMID: 37414772 Free PMC article.
The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13.
Bastida MF, Pérez-Gómez R, Trofka A, Zhu J, Rada-Iglesias A, Sheth R, Stadler HS, Mackem S, Ros MA. Bastida MF, et al. Among authors: zhu j. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096. doi: 10.1073/pnas.1919470117. Epub 2020 Jan 2. Proc Natl Acad Sci U S A. 2020. PMID: 31896583 Free PMC article.
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