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Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis.
Hilpert J, Groettrup-Wolfers E, Kosturski H, Bennett L, Barnes CLK, Gude K, Gashaw I, Reif S, Steger-Hartmann T, Scheerans C, Solms A, Rottmann A, Mao G, Chapron C. Hilpert J, et al. Among authors: gashaw i. Drugs R D. 2023 Sep;23(3):221-237. doi: 10.1007/s40268-023-00427-5. Epub 2023 Jul 9. Drugs R D. 2023. PMID: 37422772 Free PMC article. Clinical Trial.
Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study.
Friedrich C, Francke K, Gashaw I, Scheerans C, Klein S, Fels L, Smith JA, Hummel T, Morice A. Friedrich C, et al. Among authors: gashaw i. Clin Pharmacokinet. 2022 Aug;61(8):1143-1156. doi: 10.1007/s40262-022-01126-1. Epub 2022 May 28. Clin Pharmacokinet. 2022. PMID: 35624408 Free PMC article. Clinical Trial.
The Effects of Weak and Strong CYP3A Induction by Rifampicin on the Pharmacokinetics of Five Progestins and Ethinylestradiol Compared to Midazolam.
Wiesinger H, Klein S, Rottmann A, Nowotny B, Riecke K, Gashaw I, Brudny-Klöppel M, Fricke R, Höchel J, Friedrich C. Wiesinger H, et al. Among authors: gashaw i. Clin Pharmacol Ther. 2020 Oct;108(4):798-807. doi: 10.1002/cpt.1848. Epub 2020 May 11. Clin Pharmacol Ther. 2020. PMID: 32275771 Free PMC article. Clinical Trial.
Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women.
Nave R, Jodl S, Hoffmann A, Gashaw I, Zollmann F, Berse M, Höchel J, Krätzschmar J, Rohde B. Nave R, et al. Among authors: gashaw i. Reprod Sci. 2019 Apr;26(4):523-531. doi: 10.1177/1933719118776806. Epub 2018 May 27. Reprod Sci. 2019. PMID: 29806538 Clinical Trial.
Lesion kinetics in a non-human primate model of endometriosis.
Harirchian P, Gashaw I, Lipskind ST, Braundmeier AG, Hastings JM, Olson MR, Fazleabas AT. Harirchian P, et al. Among authors: gashaw i. Hum Reprod. 2012 Aug;27(8):2341-51. doi: 10.1093/humrep/des196. Epub 2012 Jun 6. Hum Reprod. 2012. PMID: 22674203 Free PMC article.
Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study.
Morice A, Smith JA, McGarvey L, Birring SS, Parker SM, Turner A, Hummel T, Gashaw I, Fels L, Klein S, Francke K, Friedrich C. Morice A, et al. Among authors: gashaw i. Eur Respir J. 2021 Nov 18;58(5):2004240. doi: 10.1183/13993003.04240-2020. Print 2021 Nov. Eur Respir J. 2021. PMID: 33986030 Free PMC article. Clinical Trial.
What makes a good drug target?
Gashaw I, Ellinghaus P, Sommer A, Asadullah K. Gashaw I, et al. Drug Discov Today. 2011 Dec;16(23-24):1037-43. doi: 10.1016/j.drudis.2011.09.007. Epub 2011 Sep 16. Drug Discov Today. 2011. PMID: 21945861 Review.
What makes a good drug target?
Gashaw I, Ellinghaus P, Sommer A, Asadullah K. Gashaw I, et al. Drug Discov Today. 2012 Feb;17 Suppl:S24-30. doi: 10.1016/j.drudis.2011.12.008. Epub 2011 Dec 11. Drug Discov Today. 2012. PMID: 22155646
36 results