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Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP. Bierhaus A, et al. Among authors: fleming t. Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Nat Med. 2012. PMID: 22581285
daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.
Mendler M, Schlotterer A, Ibrahim Y, Kukudov G, Fleming T, Bierhaus A, Riedinger C, Schwenger V, Herzig S, Hecker M, Tyedmers J, Nawroth PP, Morcos M. Mendler M, et al. Among authors: fleming t. Diabetologia. 2015 Feb;58(2):393-401. doi: 10.1007/s00125-014-3415-5. Epub 2014 Oct 17. Diabetologia. 2015. PMID: 25322843
Dicarbonyl Stress Mimics Diabetic Neurovascular Damage in the Retina.
Kolibabka M, Friedrichs P, Dietrich N, Fleming T, Schlotterer A, Hammes HP. Kolibabka M, et al. Among authors: fleming t. Exp Clin Endocrinol Diabetes. 2016 Jul;124(7):437-9. doi: 10.1055/s-0042-106081. Epub 2016 May 24. Exp Clin Endocrinol Diabetes. 2016. PMID: 27219890 Review.
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
Mendler M, Riedinger C, Schlotterer A, Volk N, Fleming T, Herzig S, Nawroth PP, Morcos M. Mendler M, et al. Among authors: fleming t. J Diabetes Complications. 2017 Feb;31(2):304-310. doi: 10.1016/j.jdiacomp.2016.09.014. Epub 2016 Oct 1. J Diabetes Complications. 2017. PMID: 27776915
The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy.
Dietrich N, Kolibabka M, Busch S, Bugert P, Kaiser U, Lin J, Fleming T, Morcos M, Klein T, Schlotterer A, Hammes HP. Dietrich N, et al. Among authors: fleming t. PLoS One. 2016 Dec 12;11(12):e0167853. doi: 10.1371/journal.pone.0167853. eCollection 2016. PLoS One. 2016. PMID: 27942008 Free PMC article.
A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage.
Niopek K, Üstünel BE, Seitz S, Sakurai M, Zota A, Mattijssen F, Wang X, Sijmonsma T, Feuchter Y, Gail AM, Leuchs B, Niopek D, Staufer O, Brune M, Sticht C, Gretz N, Müller-Decker K, Hammes HP, Nawroth P, Fleming T, Conkright MD, Blüher M, Zeigerer A, Herzig S, Berriel Diaz M. Niopek K, et al. Among authors: fleming t. Cell Rep. 2017 Aug 8;20(6):1422-1434. doi: 10.1016/j.celrep.2017.07.023. Cell Rep. 2017. PMID: 28793265 Free article.
1,169 results