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Page 1
Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism.
Pujadas EM, Wei X, Acosta N, Carter L, Yang J, Almassalha L, Daneshkhah A, Rao SSP, Agrawal V, Seker-Polat F, Aiden EL, Kanemaki MT, Backman V, Adli M. Pujadas EM, et al. bioRxiv [Preprint]. 2023 Jun 26:2023.06.26.546573. doi: 10.1101/2023.06.26.546573. bioRxiv. 2023. Update in: Genome Biol. 2024 Mar 22;25(1):77. doi: 10.1186/s13059-024-03212-y. PMID: 37425796 Free PMC article. Updated. Preprint.
Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function.
Li Y, Eshein A, Virk RKA, Eid A, Wu W, Frederick J, VanDerway D, Gladstein S, Huang K, Shim AR, Anthony NM, Bauer GM, Zhou X, Agrawal V, Pujadas EM, Jain S, Esteve G, Chandler JE, Nguyen TQ, Bleher R, de Pablo JJ, Szleifer I, Dravid VP, Almassalha LM, Backman V. Li Y, et al. Among authors: pujadas em. Sci Adv. 2021 Jan 1;7(1):eabe4310. doi: 10.1126/sciadv.abe4310. Print 2021 Jan. Sci Adv. 2021. PMID: 33523864 Free PMC article.
Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei.
Wang X, Agrawal V, Dunton CL, Liu Y, Virk RKA, Patel PA, Carter L, Pujadas EM, Li Y, Jain S, Wang H, Ni N, Tsai HM, Rivera-Bolanos N, Frederick J, Roth E, Bleher R, Duan C, Ntziachristos P, He TC, Reid RR, Jiang B, Subramanian H, Backman V, Ameer GA. Wang X, et al. Among authors: pujadas em. Nat Biomed Eng. 2023 Nov;7(11):1514-1529. doi: 10.1038/s41551-023-01053-x. Epub 2023 Jun 12. Nat Biomed Eng. 2023. PMID: 37308586 Free PMC article.
DNA density is a better indicator of a nuclear bleb than lamin B loss.
Bunner S, Prince K, Srikrishna K, Pujadas EM, McCarthy AA, Kuklinski A, Jackson O, Pellegrino P, Jagtap S, Eweka I, Lawlor C, Eastin E, Yas G, Aiello J, LaPointe N, von Blucher IS, Hardy J, Chen J, Backman V, Janssen A, Packard M, Dorfman K, Almassalha L, Bahiru MS, Stephens AD. Bunner S, et al. Among authors: pujadas em. bioRxiv [Preprint]. 2024 Feb 7:2024.02.06.579152. doi: 10.1101/2024.02.06.579152. bioRxiv. 2024. PMID: 38370828 Free PMC article. Preprint.
Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure.
Shim AR, Frederick J, Pujadas EM, Kuo T, Ye IC, Pritchard JA, Dunton CL, Gonzalez PC, Acosta N, Jain S, Anthony NM, Almassalha LM, Szleifer I, Backman V. Shim AR, et al. Among authors: pujadas em. PLoS One. 2024 May 28;19(5):e0301000. doi: 10.1371/journal.pone.0301000. eCollection 2024. PLoS One. 2024. PMID: 38805476 Free PMC article.