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Page 1
Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism.
Pujadas EM, Wei X, Acosta N, Carter L, Yang J, Almassalha L, Daneshkhah A, Rao SSP, Agrawal V, Seker-Polat F, Aiden EL, Kanemaki MT, Backman V, Adli M. Pujadas EM, et al. Among authors: rao ssp. bioRxiv [Preprint]. 2023 Jun 26:2023.06.26.546573. doi: 10.1101/2023.06.26.546573. bioRxiv. 2023. Update in: Genome Biol. 2024 Mar 22;25(1):77. doi: 10.1186/s13059-024-03212-y. PMID: 37425796 Free PMC article. Updated. Preprint.
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism.
Pujadas Liwag EM, Wei X, Acosta N, Carter LM, Yang J, Almassalha LM, Jain S, Daneshkhah A, Rao SSP, Seker-Polat F, MacQuarrie KL, Ibarra J, Agrawal V, Aiden EL, Kanemaki MT, Backman V, Adli M. Pujadas Liwag EM, et al. Among authors: rao ssp. Genome Biol. 2024 Mar 22;25(1):77. doi: 10.1186/s13059-024-03212-y. Genome Biol. 2024. PMID: 38519987 Free PMC article.
Cohesin-mediated 3D contacts tune enhancer-promoter regulation.
Guckelberger P, Doughty BR, Munson G, Rao SSP, Tan Y, Cai XS, Fulco CP, Nasser J, Mualim KS, Bergman DT, Ray J, Jagoda E, Munger CJ, Gschwind AR, Sheth MU, Tan AS, Pulido SG, Mitra N, Weisz D, Shamim MS, Durand NC, Mahajan R, Khan R, Steinmetz LM, Kanemaki MT, Lander ES, Meissner A, Aiden EL, Engreitz JM. Guckelberger P, et al. Among authors: rao ssp. bioRxiv [Preprint]. 2024 Jul 22:2024.07.12.603288. doi: 10.1101/2024.07.12.603288. bioRxiv. 2024. PMID: 39026740 Free PMC article. Preprint.
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.
Sanborn AL, Rao SS, Huang SC, Durand NC, Huntley MH, Jewett AI, Bochkov ID, Chinnappan D, Cutkosky A, Li J, Geeting KP, Gnirke A, Melnikov A, McKenna D, Stamenova EK, Lander ES, Aiden EL. Sanborn AL, et al. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6456-65. doi: 10.1073/pnas.1518552112. Epub 2015 Oct 23. Proc Natl Acad Sci U S A. 2015. PMID: 26499245 Free PMC article.
Genome Organization Drives Chromosome Fragility.
Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon KR, Pekowska A, Zhang H, Rao SSP, Huang SC, Mckinnon PJ, Aplan PD, Pommier Y, Aiden EL, Casellas R, Nussenzweig A. Canela A, et al. Among authors: rao ssp. Cell. 2017 Jul 27;170(3):507-521.e18. doi: 10.1016/j.cell.2017.06.034. Epub 2017 Jul 20. Cell. 2017. PMID: 28735753 Free PMC article.
A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.
El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, Van Blerkom P, Kieffer-Kwon P, Kieffer-Kwon KR, Park S, Wang X, Krebs J, Tripathi S, Sakabe N, Sobreira DR, Huang SC, Rao SSP, Pruett N, Chauss D, Sadler E, Lopez A, Nóbrega MA, Aiden EL, Asturias FJ, Casellas R. El Khattabi L, et al. Among authors: rao ssp. Cell. 2019 Aug 22;178(5):1145-1158.e20. doi: 10.1016/j.cell.2019.07.011. Epub 2019 Aug 8. Cell. 2019. PMID: 31402173 Free PMC article.
Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation.
Senigl F, Maman Y, Dinesh RK, Alinikula J, Seth RB, Pecnova L, Omer AD, Rao SSP, Weisz D, Buerstedde JM, Aiden EL, Casellas R, Hejnar J, Schatz DG. Senigl F, et al. Among authors: rao ssp. Cell Rep. 2019 Dec 17;29(12):3902-3915.e8. doi: 10.1016/j.celrep.2019.11.039. Cell Rep. 2019. PMID: 31851922 Free PMC article.
Cohesin depleted cells rebuild functional nuclear compartments after endomitosis.
Cremer M, Brandstetter K, Maiser A, Rao SSP, Schmid VJ, Guirao-Ortiz M, Mitra N, Mamberti S, Klein KN, Gilbert DM, Leonhardt H, Cardoso MC, Aiden EL, Harz H, Cremer T. Cremer M, et al. Among authors: rao ssp. Nat Commun. 2020 Dec 1;11(1):6146. doi: 10.1038/s41467-020-19876-6. Nat Commun. 2020. PMID: 33262376 Free PMC article.
23 results