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Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle.
Colina-Vegas L, da Cruz B Silva M, de Souza Pereira C, Isis Barros A, Araújo Nobrega J, Navarro M, Rottmann M, D'Alessandro S, Basilico N, Azevedo Batista A, Moreira DRM. Colina-Vegas L, et al. Among authors: rottmann m. Chemistry. 2023 Oct 2;29(55):e202301642. doi: 10.1002/chem.202301642. Epub 2023 Aug 18. Chemistry. 2023. PMID: 37427863
Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies.
Cesar-Rodo E, Dupouy B, Häberli C, Strub JM, Williams DL, Mäser P, Rottmann M, Keiser J, Lanfranchi DA, Davioud-Charvet E. Cesar-Rodo E, et al. Among authors: rottmann m. Molecules. 2024 Nov 7;29(22):5268. doi: 10.3390/molecules29225268. Molecules. 2024. PMID: 39598657 Free PMC article.
Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity.
Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany AM, Hahne H, Rottmann M, Witschel M, Odom John A, Hamed MM, Diamanti E, Hirsch AKH. Willocx D, et al. Among authors: rottmann m. J Med Chem. 2024 Oct 10;67(19):17070-17086. doi: 10.1021/acs.jmedchem.4c00212. Epub 2024 Sep 20. J Med Chem. 2024. PMID: 39303294 Free PMC article.
Targeting the Plasmodium falciparum IspE Enzyme.
Diamanti E, Steinbach AM, de Carvalho LP, Ropponen HK, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, Fischer M, Hamed MM, Bach NC, Rottmann M, Held J, Witschel M, Sieber SA, Hirsch AKH. Diamanti E, et al. Among authors: rottmann m. ACS Omega. 2024 Oct 25;9(44):44465-44473. doi: 10.1021/acsomega.4c06038. eCollection 2024 Nov 5. ACS Omega. 2024. PMID: 39524657 Free PMC article.
3-Benzylmenadiones and their Heteroaromatic Analogues Target the Apicoplast of Apicomplexa Parasites: Synthesis and Bioimaging Studies.
Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh M, Bordat Y, Rottmann M, Mäser P, Botté CY, Blandin SA, Besteiro S, Davioud-Charvet E. Dupouy B, et al. Among authors: rottmann m. ACS Infect Dis. 2024 Oct 11;10(10):3553-3576. doi: 10.1021/acsinfecdis.4c00304. Epub 2024 Sep 26. ACS Infect Dis. 2024. PMID: 39327729
Tambjamines as Fast-Acting Multistage Antimalarials.
Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. Kumar A, et al. Among authors: rottmann m. ACS Infect Dis. 2024 Dec 13;10(12):4291-4300. doi: 10.1021/acsinfecdis.4c00659. Epub 2024 Nov 11. ACS Infect Dis. 2024. PMID: 39526703 Free PMC article.
142 results