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A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Rodrigues FF, Lino CI, Oliveira VLS, Zaidan I, Melo ISF, Braga AV, Costa SOAM, Morais MI, Barbosa BCM, da Costa YFG, Moreira NF, Alves MS, Braga AD, Carneiro FS, Carvalho AFS, Queiroz-Junior CM, Sousa LP, Amaral FA, Oliveira RB, Coelho MM, Machado RR. Rodrigues FF, et al. Among authors: braga ad. Int Immunopharmacol. 2023 Sep;122:110609. doi: 10.1016/j.intimp.2023.110609. Epub 2023 Jul 8. Int Immunopharmacol. 2023. PMID: 37429145 Free article.
Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout.
Tavares LD, Galvão I, Costa VV, Batista NV, Rossi LCR, Brito CB, Reis AC, Queiroz-Junior CM, Braga AD, Coelho FM, Dias AC, Zamboni DS, Pinho V, Teixeira MM, Amaral FA, Souza DG. Tavares LD, et al. Among authors: braga ad. J Leukoc Biol. 2019 Sep;106(3):619-629. doi: 10.1002/JLB.MA1118-470RR. Epub 2019 Aug 8. J Leukoc Biol. 2019. PMID: 31392775
S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity.
Mambelli F, Santos BPO, Morais SB, Gimenez EGT, Astoni DCDS, Braga AD, Ferreira RS, Amaral FA, de Magalhães MTQ, Oliveira SC. Mambelli F, et al. Among authors: braga ad. PLoS Negl Trop Dis. 2021 Jan 19;15(1):e0009007. doi: 10.1371/journal.pntd.0009007. eCollection 2021 Jan. PLoS Negl Trop Dis. 2021. PMID: 33465126 Free PMC article.
12 results