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A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Rodrigues FF, Lino CI, Oliveira VLS, Zaidan I, Melo ISF, Braga AV, Costa SOAM, Morais MI, Barbosa BCM, da Costa YFG, Moreira NF, Alves MS, Braga AD, Carneiro FS, Carvalho AFS, Queiroz-Junior CM, Sousa LP, Amaral FA, Oliveira RB, Coelho MM, Machado RR. Rodrigues FF, et al. Int Immunopharmacol. 2023 Sep;122:110609. doi: 10.1016/j.intimp.2023.110609. Epub 2023 Jul 8. Int Immunopharmacol. 2023. PMID: 37429145 Free article.
Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund's adjuvant.
Menezes RR, Godin AM, Rodrigues FF, Coura GME, Melo ISF, Brito AMS, Bertollo CM, Paulino TP, Rachid MA, Machado RR, Coelho MM. Menezes RR, et al. Among authors: rodrigues ff. Pharmacol Rep. 2017 Oct;69(5):1036-1043. doi: 10.1016/j.pharep.2017.04.011. Epub 2017 Apr 23. Pharmacol Rep. 2017. PMID: 28958614
Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1.
Brito AMS, Godin AM, Augusto PSA, Menezes RR, Melo ISF, Dutra MGMB, Costa SOAM, Goulart FA, Rodrigues FF, Ísis Morais M, Machado RR, Coelho MM. Brito AMS, et al. Among authors: rodrigues ff. Eur J Pharmacol. 2018 Jan 5;818:17-25. doi: 10.1016/j.ejphar.2017.10.026. Epub 2017 Oct 16. Eur J Pharmacol. 2018. PMID: 29042208
4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-α and CXCL1 production and exhibits activity in models of pain and inflammation.
Melo ISF, Rodrigues FF, Costa SOAM, Braga AV, Morais MÍ, Vaz JA, Neto LS, Galvão I, Modolo LV, Amaral FA, Oliveira RB, de Fátima Â, Coelho MM, Machado RR. Melo ISF, et al. Among authors: rodrigues ff. Eur J Pharmacol. 2019 Aug 5;856:172404. doi: 10.1016/j.ejphar.2019.172404. Epub 2019 May 24. Eur J Pharmacol. 2019. PMID: 31132352 Free article.
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Augusto PSA, Braga AV, Rodrigues FF, Morais MI, Dutra MMGB, Batista CRA, Melo ISF, Costa SOAM, Goulart FA, Coelho MM, Machado RR. Augusto PSA, et al. Among authors: rodrigues ff. Eur J Pharmacol. 2019 Sep 5;858:172497. doi: 10.1016/j.ejphar.2019.172497. Epub 2019 Jun 22. Eur J Pharmacol. 2019. PMID: 31238066 Free article.
114 results