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From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Visser EJ, Jaishankar P, Sijbesma E, Pennings MAM, Vandenboorn EMF, Guillory X, Neitz RJ, Morrow J, Dutta S, Renslo AR, Brunsveld L, Arkin MR, Ottmann C. Visser EJ, et al. Among authors: vandenboorn emf. Angew Chem Int Ed Engl. 2023 Sep 11;62(37):e202308004. doi: 10.1002/anie.202308004. Epub 2023 Aug 1. Angew Chem Int Ed Engl. 2023. PMID: 37455289 Free PMC article.
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.
Konstantinidou M, Visser EJ, Vandenboorn E, Chen S, Jaishankar P, Overmans M, Dutta S, Neitz RJ, Renslo AR, Ottmann C, Brunsveld L, Arkin MR. Konstantinidou M, et al. J Am Chem Soc. 2023 Sep 20;145(37):20328-20343. doi: 10.1021/jacs.3c05161. Epub 2023 Sep 7. J Am Chem Soc. 2023. PMID: 37676236 Free PMC article.
Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression.
Desmet SJ, Thommis J, Vanderhaeghen T, Vandenboorn EMF, Clarisse D, Li Y, Timmermans S, Fijalkowska D, Ratman D, Van Hamme E, De Cauwer L, Staels B, Brunsveld L, Peelman F, Libert C, Tavernier J, De Bosscher K. Desmet SJ, et al. Among authors: vandenboorn emf. Mol Metab. 2024 Jun;84:101938. doi: 10.1016/j.molmet.2024.101938. Epub 2024 Apr 15. Mol Metab. 2024. PMID: 38631478 Free PMC article.