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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy.
Altman MC, Segnitz RM, Larson D, Jayavelu ND, Smith MT, Patel S, Scadding GW, Qin T, Sanda S, Steveling E, Eifan AO, Penagos M, Jacobson MR, Parkin RV, Shamji MH, Togias A, Durham SR. Altman MC, et al. Among authors: jacobson mr. J Allergy Clin Immunol. 2023 Nov;152(5):1247-1260. doi: 10.1016/j.jaci.2023.06.025. Epub 2023 Jul 15. J Allergy Clin Immunol. 2023. PMID: 37460024 Free PMC article. Clinical Trial.
Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells.
Scadding GW, Shamji MH, Jacobson MR, Lee DI, Wilson D, Lima MT, Pitkin L, Pilette C, Nouri-Aria K, Durham SR. Scadding GW, et al. Among authors: jacobson mr. Clin Exp Allergy. 2010 Apr;40(4):598-606. doi: 10.1111/j.1365-2222.2010.03462.x. Epub 2010 Feb 22. Clin Exp Allergy. 2010. PMID: 20184605 Clinical Trial.
Immunotherapy and allergic inflammation.
Durham SR, Varney V, Gaga M, Frew AJ, Jacobson M, Kay AB. Durham SR, et al. Clin Exp Allergy. 1991 Jan;21 Suppl 1:206-10. doi: 10.1111/j.1365-2222.1991.tb01729.x. Clin Exp Allergy. 1991. PMID: 2032147 Clinical Trial.
Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma.
Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, Kay AB, Hamid QA. Durham SR, et al. Among authors: jacobson mr. J Allergy Clin Immunol. 1996 Jun;97(6):1356-65. doi: 10.1016/s0091-6749(96)70205-1. J Allergy Clin Immunol. 1996. PMID: 8648033 Clinical Trial.
92 results