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VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept.
Sharma D, Lau E, Qin Y, Jee K, Rodrigues M, Guo C, Dinabandhu A, McIntyre E, Salman S, Hwang Y, Moshiri A, Semenza GL, Montaner S, Sodhi A. Sharma D, et al. Among authors: moshiri a. Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2322759121. doi: 10.1073/pnas.2322759121. Epub 2024 Nov 5. Proc Natl Acad Sci U S A. 2024. PMID: 39499641 Free PMC article.
Safety and efficacy of CRISPR-mediated genome ablation of VEGFA as a treatment for choroidal neovascularization in nonhuman primate eyes.
Sin TN, Tng N, Dragoli J, Ramesh Kumar S, Villafuerte-Trisolini C, Chung SH, Tu L, Le SM, Shim JH, Pepple KL, Ravindran R, Khan IH, Moshiri A, Thomasy SM, Yiu G. Sin TN, et al. Among authors: moshiri a. Mol Ther. 2024 Sep 27:S1525-0016(24)00651-8. doi: 10.1016/j.ymthe.2024.09.027. Online ahead of print. Mol Ther. 2024. PMID: 39342431
Edetate Disodium-Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes: TACT2 Randomized Clinical Trial.
Lamas GA, Anstrom KJ, Navas-Acien A, Boineau R, Nemeth H, Huang Z, Wen J, Rosenberg Y, Stylianou M, Jones TLZ, Joubert BR, Yu Q, Santella RM, Mon AC, Ujueta F, Escolar E, Nathan DM, Fonseca VA, Aude YW, Ehrman JK, Elliott T, Prashad R, Lewis EF, Lopes RD, Farkouh ME, Elliott AM, Newman JD, Mark DB; TACT2 Investigators. Lamas GA, et al. JAMA. 2024 Sep 10;332(10):794-803. doi: 10.1001/jama.2024.11463. JAMA. 2024. PMID: 39141382 Clinical Trial.
Single cell dual-omic atlas of the human developing retina.
Zuo Z, Cheng X, Ferdous S, Shao J, Li J, Bao Y, Li J, Lu J, Jacobo Lopez A, Wohlschlegel J, Prieve A, Thomas MG, Reh TA, Li Y, Moshiri A, Chen R. Zuo Z, et al. Among authors: moshiri a. Nat Commun. 2024 Aug 9;15(1):6792. doi: 10.1038/s41467-024-50853-5. Nat Commun. 2024. PMID: 39117640 Free PMC article.
237 results