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Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.
Bonifazi A, Saab E, Sanchez J, Nazarova AL, Zaidi SA, Jahan K, Katritch V, Canals M, Lane JR, Newman AH. Bonifazi A, et al. Among authors: newman ah. J Med Chem. 2023 Aug 10;66(15):10304-10341. doi: 10.1021/acs.jmedchem.3c00417. Epub 2023 Jul 19. J Med Chem. 2023. PMID: 37467430 Free PMC article.
Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinan.
de Costa BR, Iadarola MJ, Rothman RB, Berman KF, George C, Newman AH, Mahboubi A, Jacobson AE, Rice KC. de Costa BR, et al. Among authors: newman ah. J Med Chem. 1992 Jul 24;35(15):2826-35. doi: 10.1021/jm00093a016. J Med Chem. 1992. PMID: 1322988
334 results