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A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging.
Pun FW, Leung GHD, Leung HW, Rice J, Schmauck-Medina T, Lautrup S, Long X, Liu BHM, Wong CW, Ozerov IV, Aliper A, Ren F, Rosenberg AJ, Agrawal N, Izumchenko E, Fang EF, Zhavoronkov A. Pun FW, et al. Among authors: leung ghd. Aging Cell. 2023 Dec;22(12):e14017. doi: 10.1111/acel.14017. Epub 2023 Oct 27. Aging Cell. 2023. PMID: 37888486 Free PMC article.
Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform.
Pun FW, Liu BHM, Long X, Leung HW, Leung GHD, Mewborne QT, Gao J, Shneyderman A, Ozerov IV, Wang J, Ren F, Aliper A, Bischof E, Izumchenko E, Guan X, Zhang K, Lu B, Rothstein JD, Cudkowicz ME, Zhavoronkov A. Pun FW, et al. Among authors: leung ghd. Front Aging Neurosci. 2022 Jun 28;14:914017. doi: 10.3389/fnagi.2022.914017. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35837482 Free PMC article.
Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation.
Sidorenko D, Pushkov S, Sakip A, Leung GHD, Lok SWY, Urban A, Zagirova D, Veviorskiy A, Tihonova N, Kalashnikov A, Kozlova E, Naumov V, Pun FW, Aliper A, Ren F, Zhavoronkov A. Sidorenko D, et al. Among authors: leung ghd. NPJ Aging. 2024 Aug 8;10(1):37. doi: 10.1038/s41514-024-00163-3. NPJ Aging. 2024. PMID: 39117678 Free PMC article.
Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery.
Urban A, Sidorenko D, Zagirova D, Kozlova E, Kalashnikov A, Pushkov S, Naumov V, Sarkisova V, Leung GHD, Leung HW, Pun FW, Ozerov IV, Aliper A, Ren F, Zhavoronkov A. Urban A, et al. Among authors: leung ghd. Aging (Albany NY). 2023 Jun 13;15(11):4649-4666. doi: 10.18632/aging.204788. Epub 2023 Jun 13. Aging (Albany NY). 2023. PMID: 37315204 Free PMC article.
Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform.
Olsen A, Harpaz Z, Ren C, Shneyderman A, Veviorskiy A, Dralkina M, Konnov S, Shcheglova O, Pun FW, Leung GHD, Leung HW, Ozerov IV, Aliper A, Korzinkin M, Zhavoronkov A. Olsen A, et al. Among authors: leung ghd. Aging (Albany NY). 2023 Apr 26;15(8):2863-2876. doi: 10.18632/aging.204678. Epub 2023 Apr 26. Aging (Albany NY). 2023. PMID: 37100462 Free PMC article.
Leveraging AI to identify dual-purpose aging and disease targets.
Leung GHD, Wong CW, Pun FW, Aliper A, Ren F, Zhavoronkov A. Leung GHD, et al. Expert Opin Ther Targets. 2024 Jun;28(6):473-476. doi: 10.1080/14728222.2023.2288270. Epub 2023 Dec 1. Expert Opin Ther Targets. 2024. PMID: 38038952 No abstract available.
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