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The small molecule Erk1/2 signaling pathway inhibitor PD98059 improves DNA repair in an experimental autoimmune encephalomyelitis SJL/J mouse model of multiple sclerosis.
Attia SM, Ahmad SF, Nadeem A, Attia MSM, Ansari MA, Alsaleh NB, Alasmari AF, Al-Hamamah MA, Alanazi A, Alshamrani AA, Bakheet SA, Harisa GI. Attia SM, et al. Among authors: alasmari af. Mutat Res Genet Toxicol Environ Mutagen. 2023 Jul;889:503650. doi: 10.1016/j.mrgentox.2023.503650. Epub 2023 Jun 3. Mutat Res Genet Toxicol Environ Mutagen. 2023. PMID: 37491119
Apremilast prevent doxorubicin-induced apoptosis and inflammation in heart through inhibition of oxidative stress mediated activation of NF-κB signaling pathways.
Imam F, Al-Harbi NO, Al-Harbi MM, Ansari MA, Al-Asmari AF, Ansari MN, Al-Anazi WA, Bahashwan S, Almutairi MM, Alshammari M, Khan MR, Alsaad AM, Alotaibi MR. Imam F, et al. Pharmacol Rep. 2018 Oct;70(5):993-1000. doi: 10.1016/j.pharep.2018.03.009. Epub 2018 Mar 29. Pharmacol Rep. 2018. PMID: 30118964
The histamine-4 receptor antagonist JNJ7777120 prevents immune abnormalities by inhibiting RORγt/T-bet transcription factor signaling pathways in BTBR T+ Itpr3tf/J mice exposed to gamma rays.
Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, Al-Mazroua HA, Khan MR, Alasmari AF, Alanazi WA, As Sobeai HM, Attia SM. Ahmad SF, et al. Among authors: alasmari af. Mol Immunol. 2019 Oct;114:561-570. doi: 10.1016/j.molimm.2019.09.007. Epub 2019 Sep 12. Mol Immunol. 2019. PMID: 31522074
The potent immunomodulatory compound VGX-1027 regulates inflammatory mediators in CD4+ T cells, which are concomitant with the prevention of neuroimmune dysregulation in BTBR T+ Itpr3tf/J mice.
Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, Alasmari F, Alasmari AF, Al-Kharashi LA, Al-Qahtani QH, Attia SM. Ahmad SF, et al. Among authors: alasmari af, alasmari f. Life Sci. 2019 Nov 15;237:116930. doi: 10.1016/j.lfs.2019.116930. Epub 2019 Oct 11. Life Sci. 2019. PMID: 31610190
Upregulation of enzymatic antioxidants in CD4+ T cells of autistic children.
Nadeem A, Ahmad SF, Al-Harbi NO, Alasmari AF, Al-Ayadhi LY, Alasmari F, Ibrahim KE, Attia SM, Bakheet SA. Nadeem A, et al. Among authors: alasmari af, alasmari f. Biochimie. 2020 Apr-May;171-172:205-212. doi: 10.1016/j.biochi.2020.03.009. Epub 2020 Mar 12. Biochimie. 2020. PMID: 32173487
Involvement of CD45 cells in the development of autism spectrum disorder through dysregulation of granulocyte-macrophage colony-stimulating factor, key inflammatory cytokines, and transcription factors.
Ahmad SF, Ansari MA, Nadeem A, Bakheet SA, Al-Ayadhi LY, Alasmari AF, Alanazi MM, Al-Mazroua HA, Attia SM. Ahmad SF, et al. Among authors: alasmari af. Int Immunopharmacol. 2020 Jun;83:106466. doi: 10.1016/j.intimp.2020.106466. Epub 2020 Apr 4. Int Immunopharmacol. 2020. PMID: 32259699
185 results