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Page 1
Synthesis, spectroscopic characterization, and antibacterial activity of chalcone (2E)-1-(3'-aminophenyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one against multiresistant Staphylococcus aureus carrier of efflux pump mechanisms and β-lactamase.
da Silva L, Donato IA, Bezerra SR, Dos Santos HS, Bandeira PN, do Nascimento MTR, Guedes JM, Freitas PR, de Araújo ACJ, de Freitas TS, Coutinho HDM, de Matos YMLS, de Oliveira LCC, da Cunha FAB. da Silva L, et al. Among authors: freitas pr. Fundam Clin Pharmacol. 2024 Feb;38(1):60-71. doi: 10.1111/fcp.12938. Epub 2023 Jul 27. Fundam Clin Pharmacol. 2024. PMID: 37497790
Photobiological effect of eugenol-derived 3-benzoylcoumarin associated with led lights against MDR microorganisms.
de Sousa AK, Rocha JE, de Freitas TS, Freitas PR, Pereira RLS, Júnior FNP, Brancaglion GA, de Paulo DC, Carvalho DT, de Menezes IRA, Dos Santos FAV, Coutinho HDM, Júnior LJQ. de Sousa AK, et al. Among authors: freitas pr. Fundam Clin Pharmacol. 2023 Apr;37(2):316-323. doi: 10.1111/fcp.12838. Epub 2022 Oct 11. Fundam Clin Pharmacol. 2023. PMID: 36205463
In silico and in vitro evaluation of efflux pumps inhibition of α,β-amyrin.
Oliveira RC, Bandeira PN, Lemos TLG, Dos Santos HS, Scherf JR, Rocha JE, Pereira RLS, Freitas TS, Freitas PR, Pereira-Junior FN, Marinho MM, Marinho EM, Marinho ES, Nogueira CES, Coutinho HDM, Teixeira AMR. Oliveira RC, et al. Among authors: freitas pr, freitas ts. J Biomol Struct Dyn. 2022;40(23):12785-12799. doi: 10.1080/07391102.2021.1976277. Epub 2021 Sep 16. J Biomol Struct Dyn. 2022. PMID: 34528866
Dihydroeugenol derivatives associated with blue LED light: A different form to face multidrug resistant (MDR) bacteria.
de Sousa AK, Rocha JE, de Freitas TS, Freitas PR, Pereira RLS, Leandro MKDNS, Machado JVC, de Oliveira LM, Torres Sierra EJ, Pereira Júnior FN, Carvalho DT, Coutinho HDM, Quintans Júnior LJ. de Sousa AK, et al. Among authors: freitas pr. Microb Pathog. 2022 Dec;173(Pt A):105827. doi: 10.1016/j.micpath.2022.105827. Epub 2022 Oct 13. Microb Pathog. 2022. PMID: 36243385
Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches.
Freitas PR, Araújo ACJ, Araújo IM, Almeida RS, Oliveira Borges JA, Lima CMG, Oliveira-Tintino CDM, Paulo CLR, Miranda GM, Araújo-Neto JB, Almeida-Bezerra JW, Nascimento IJDS, Araújo-Júnior JX, Silva-Júnior EFD, Aquino TM, Mendonca Junior FJB, Marinho ES, Santos HSD, Menezes IRA, Tintino SR, Coutinho HDM. Freitas PR, et al. Biochimie. 2024 Dec 19:S0300-9084(24)00313-4. doi: 10.1016/j.biochi.2024.12.009. Online ahead of print. Biochimie. 2024. PMID: 39708974
Liposomal formulation with thiazolic compounds against bacterial efflux pumps.
de Almeida RS, Freitas PR, Justino de Araujo AC, Tintino SR, Ribeiro-Filho J, Miranda GM, Sigueira GM, Gonçalves SA, Carvalho DT, de Souza TB, Santos Folquitto LRD, Dias DF, Raposo A, Saraiva A, Han H, Coutinho HDM. de Almeida RS, et al. Among authors: freitas pr. Biomed Pharmacother. 2024 Nov;180:117600. doi: 10.1016/j.biopha.2024.117600. Epub 2024 Oct 30. Biomed Pharmacother. 2024. PMID: 39476763 Free article.
Molecular Docking and Antibacterial Activity of Campesterol Derivatives Against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa Multiresistant Strains.
de Morais Oliveira-Tintino CD, da Silva FEF, Santiago GMP, das C L Pinto F, Pessoa ODL, da Fonseca AM, Paulo CLR, Dos Santos HS, Marinho MM, Dos Santos JL, Moura TF, Freitas PR, de Araújo ACJ, de Almeida RS, Tintino SR, Coutinho HDM. de Morais Oliveira-Tintino CD, et al. Among authors: freitas pr. Chem Biodivers. 2024 Sep 11:e202401073. doi: 10.1002/cbdv.202401073. Online ahead of print. Chem Biodivers. 2024. PMID: 39258811
Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors.
de Araújo ACJ, Freitas PR, Araújo IM, de Oliveira Borges JA, Gonçalves SA, Paulo CLR, Almeida RS, de Moraes Oliveira-Tintino CD, de Araújo-Neto JB, Dos Santos Nascimento IJ, de Araújo-Júnior JX, da Silva-Júnior EF, de Aquino TM, Junior FJBM, Marinho ES, Dos Santos HS, de Alencar Menezes IR, Tintino SR, Coutinho HDM, Braga MFBM. de Araújo ACJ, et al. Among authors: freitas pr. Curr Microbiol. 2024 Aug 24;81(10):325. doi: 10.1007/s00284-024-03836-0. Curr Microbiol. 2024. PMID: 39182011
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration.
Freitas PR, de Araújo ACJ, Araújo IM, de Almeida RS, Borges JAO, Paulo CLR, Oliveira-Tintino CDM, Miranda GM, Araújo-Neto JB, Nascimento IJS, Araújo-Júnior JX, Silva JMA, Balbino TCL, Silva-Júnior EF, Aquino TM, Mendonca-Junior FJB, Marinho ES, Santos HS, Lima CMG, Obaidullah AJ, Bin Emran T, Cunha FAB, Menezes IRA, Tintino SR, Coutinho HDM. Freitas PR, et al. Biomed Pharmacother. 2024 Oct;179:117291. doi: 10.1016/j.biopha.2024.117291. Epub 2024 Aug 14. Biomed Pharmacother. 2024. PMID: 39146766 Free article.
Chemical composition and antibacterial effects of Etlingera elatior (Jack) R.M. Smith against Staphylococcus aureus efflux pumps.
de Sousa Ferreira F, de Araújo Neto JB, de Morais Oliveira-Tintino CD, de Araújo ACJ, Ribeiro-Filho J, Freitas PR, Araújo IM, Lima MA, de Azevedo FR, Tintino SR, Coutinho HDM, Navarro DMDAF. de Sousa Ferreira F, et al. Among authors: freitas pr. Chem Biol Interact. 2023 Dec 1;386:110751. doi: 10.1016/j.cbi.2023.110751. Epub 2023 Oct 10. Chem Biol Interact. 2023. PMID: 37821044
36 results