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Page 1
Protective intravenous BCG vaccination induces enhanced immune signaling in the airways.
Peters JM, Irvine EB, Rosenberg JM, Wadsworth MH, Hughes TK, Sutton M, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Flynn JL, Shalek AK, Fortune SM, Bryson BD. Peters JM, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2023 Jul 18:2023.07.16.549208. doi: 10.1101/2023.07.16.549208. bioRxiv. 2023. Update in: Sci Adv. 2025 Jan 3;11(1):eadq8229. doi: 10.1126/sciadv.adq8229 PMID: 37502895 Free PMC article. Updated. Preprint.
Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guérin vaccination in rhesus macaques.
Irvine EB, Darrah PA, Wang S, Wang C, McNamara RP, Roederer M, Seder RA, Lauffenburger DA, Flynn JL, Fortune SM, Alter G. Irvine EB, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2023 Aug 2:2023.07.31.551245. doi: 10.1101/2023.07.31.551245. bioRxiv. 2023. Update in: iScience. 2024 Oct 15;27(12):111128. doi: 10.1016/j.isci.2024.111128 PMID: 37577655 Free PMC article. Updated. Preprint.
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker B, Gardner M, Guinn KM, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2023 Nov 19:2023.11.19.567569. doi: 10.1101/2023.11.19.567569. bioRxiv. 2023. PMID: 38014062 Free PMC article. Preprint.
CD4+ T cells are homeostatic regulators during Mtb reinfection.
Bromley JD, Ganchua SKC, Nyquist SK, Maiello P, Chao M, Borish HJ, Rodgers M, Tomko J, Kracinovsky K, Mugahid D, Nguyen S, Wang D, Rosenberg JM, Klein EC, Gideon HP, Floyd-O'Sullivan R, Berger B, Scanga CA, Lin PL, Fortune SM, Shalek AK, Flynn JL. Bromley JD, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2023 Dec 21:2023.12.20.572669. doi: 10.1101/2023.12.20.572669. bioRxiv. 2023. PMID: 38187598 Free PMC article. Preprint.
Antibiotic treatment modestly reduces protection against Mycobacterium tuberculosis reinfection in macaques.
Ganchua SK, Maiello P, Chao M, Hopkins F, Mugahid D, Lin PL, Fortune SM, Flynn JL. Ganchua SK, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2024 Feb 24:2023.12.19.570845. doi: 10.1101/2023.12.19.570845. bioRxiv. 2024. Update in: Infect Immun. 2024 Apr 9;92(4):e0053523. doi: 10.1128/iai.00535-23 PMID: 38187678 Free PMC article. Updated. Preprint.
CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques.
Simonson AW, Zeppa JJ, Bucsan AN, Chao MC, Pokkali S, Hopkins F, Chase MR, Vickers AJ, Sutton MS, Winchell CG, Myers AJ, Ameel CL, Kelly R, Krouse B, Hood LE, Li J, Lehman CC, Kamath M, Tomko J, Rodgers MA, Donlan R, Chishti H, Jacob Borish H, Klein E, Scanga CA, Fortune S, Lin PL, Maiello P, Roederer M, Darrah PA, Seder RA, Flynn JL. Simonson AW, et al. bioRxiv [Preprint]. 2024 May 17:2024.05.14.594183. doi: 10.1101/2024.05.14.594183. bioRxiv. 2024. PMID: 38798646 Free PMC article. Preprint.
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.
Grace PS, Peters JM, Sixsmith J, Lu R, Luedeman C, Fenderson BA, Vickers A, Slein MD, Irvine EB, McKitrick T, Wei MH, Cummings RD, Wallace A, Cavacini LA, Choudhary A, Proulx MK, Sundling C, Källenius G, Reljic R, Ernst JD, Casadevall A, Locht C, Pinter A, Sasseti CM, Bryson BD, Fortune SM, Alter G. Grace PS, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2024 Oct 11:2024.10.07.617070. doi: 10.1101/2024.10.07.617070. bioRxiv. 2024. PMID: 39416184 Free PMC article. Preprint.
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection.
Bromley JD, Ganchua SKC, Nyquist SK, Maiello P, Chao M, Borish HJ, Rodgers M, Tomko J, Kracinovsky K, Mugahid D, Nguyen S, Wang QD, Rosenberg JM, Klein EC, Gideon HP, Floyd-O'Sullivan R, Berger B, Scanga CA, Lin PL, Fortune SM, Shalek AK, Flynn JL. Bromley JD, et al. Among authors: fortune sm. Immunity. 2025 Jan 15:S1074-7613(25)00001-9. doi: 10.1016/j.immuni.2025.01.001. Online ahead of print. Immunity. 2025. PMID: 39818207 Free article. No abstract available.
Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker BJ, Gardner M, Guinn KM, Howard NC, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: fortune sm. Nat Microbiol. 2025 Jan 10. doi: 10.1038/s41564-024-01913-5. Online ahead of print. Nat Microbiol. 2025. PMID: 39794471
High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways.
Peters JM, Irvine EB, Makatsa MS, Rosenberg JM, Wadsworth MH 2nd, Hughes TK, Sutton MS, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Seshadri C, Flynn JL, Shalek AK, Fortune SM, Bryson BD. Peters JM, et al. Among authors: fortune sm. Sci Adv. 2025 Jan 3;11(1):eadq8229. doi: 10.1126/sciadv.adq8229. Epub 2025 Jan 1. Sci Adv. 2025. PMID: 39742484 Free PMC article.
142 results